The spino-parabrachio-amygdaloid pathway is critical for the manifestation of chronic pain.
The spino-parabrachio-amygdaloid pathway is critical for the manifestation of chronic pain.
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脊髓-旁臂肌-杏仁通路对于慢性疼痛的表现至关重要。
DOI：
10.1038/s41386-023-01745-7
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Allen,HeatherN
中科院分区：
文献类型：
--
作者：
Nelson,TylerS;Allen,HeatherN
疼痛是一种复杂的现象，它会引起躯体感觉和运动反射反应，以及持久的情绪和自主神经变化。虽然疼痛是一种保护机制，可以发出潜在伤害的信号，鼓励人们回避，但它也可以成为持续性和病理性的，扰乱正常的功能和生活质量。为了有效地解决慢性疼痛，必须增加我们对神经通路的可塑性的了解，该通路将伤害性感觉信息从皮肤的周围神经末梢传递到促进认知的高级大脑区域。Bernard和Bessonls的开创性工作强调了脊椎-臂旁-杏仁体通路在伤害性躯体感觉信息的上行传递中的关键作用[1]。在大鼠的细胞外电生理记录中发现臂旁核(PBN)中投射到杏仁中央核(CEA)的伤害性特异性神经元。PBN→CEA神经元对各种伤害性机械和热刺激表现出广泛的感受野和分级反应，一致地编码外周刺激的强度[1]。PBN是一种双侧桥脑结构，从外周伤害性感受器、脊髓背角投射神经元和其他脑干区接收汇聚的伤害性信息。然后，PBN将这些上升信息传递到中脑和前脑区域，以整合情绪和认知输入。CEA是位于中脑的杏仁状双侧核，对处理和调节情绪反应，特别是恐惧和焦虑是不可或缺的。因此，PBN→CEA神经元的可塑性被假设为不适应性疼痛时序和疼痛厌恶的中心机制[2]。
Pain is a complex phenomenon that elicits somatosensory and motor reflexive responses alongside enduring emotional and autonomic changes. Although pain serves as a protective mechanism to signal potential harm and encourage avoidance, it can also become persistent and pathological, disrupting regular functioning and quality of life. To effectively address chronic pain, it is imperative to increase our understanding of plasticity in the neural pathways that transmit nociceptive sensory information from peripheral nerve endings in the skin to higher-order brain areas facilitating cognition.Bernard and BessonLs pioneering work highlighted the crucial role of the spino-parabrachio-amygdaloid pathway in the ascending transmission of noxious somatosensory information [1]. Extracellular electrophysiological recordings in rats identified nociception-specific neurons in the parabrachial nucleus (PBN) that project to the central nucleus of the amygdala (CeA). PBN→ CeA neurons displayed broad receptive fields and graded responses to various noxious mechanical and thermal stimuli, consistently encoding the intensity of peripheral stimulation [1]. The PBN is a bilateral pontine brain structure that receives converging nociceptive information from peripheral nociceptors, spinal cord dorsal horn projection neurons, and other brainstem regions. The PBN then relays this ascending information to midbrain and forebrain regions for integration with emotional and cognitive inputs. The CeA is a bilateral almond shaped brain nucleus in the midbrain that is integral to processing and regulating emotional responses, particularly fear and anxiety. Thus, plasticity of PBN→ CeA neurons is hypothesized to be a central mechanism for maladaptive pain chronification and pain aversion [2].