Origin and epidemic status of porcine epidemic diarrhea virus variants in China
Origin and epidemic status of porcine epidemic diarrhea virus variants in China
复制标题
中国猪流行性腹泻病毒变种的起源及流行现状
DOI：
10.1111/tbed.13444
复制
发表时间：
2019-12-16
影响因子：
4.3
通讯作者：
Li, Bin
中科院分区：
文献类型：
--
作者：
Fan, Baochao;Jiao, Dian;Li, Bin
自2010年以来，猪流行性腹泻病毒（PEDV）变异株在亚洲和美国连续爆发疾病。在这项回顾性研究中，从2014年至2016年在中国收集的PEDV毒株中获得了49个完整的刺突（S）基因序列。我们观察到PEDV变异株具有新的插入，缺失和多重S基因重组类型在中国存在。此外，在一些地区还观察到涉及不同变异株的混合感染。基于系统发育和重组分析，我们确定新出现的PEDV变异体可能起源于最早的中国G1基因组毒株JS-2004-2和早期韩国大流行毒株之间的重组。这些发现为理解正在进行的PEDV爆发提供了重要信息，并表明新的变体使预防PEDV感染变得更加困难。
From 2010, porcine epidemic diarrhea virus (PEDV) variants caused sequential outbreaks of disease in Asia and the United States. In this retrospective study, 49 complete spike (S) gene sequences were obtained from PEDV strains collected in China from 2014 to 2016. We observed that variant PEDV strains with novel insertions, deletions, and multiple S gene recombination types were present in China. In addition, mixed infections involving different variant strains were observed in some areas. Based on phylogenetic and recombination analyses, we determined that the newly emerged PEDV variants potentially originated via recombination between the earliest Chinese G1 genogroup strain, JS-2004-2 and earlier Korean pandemic strains. These findings provide important information for understanding ongoing PEDV outbreaks and suggest that novel variants make it more difficult to prevent PEDV infection.