A nonlinear constituent based viscoelastic model for articular cartilage and analysis of tissue remodeling due to altered glycosaminoglycan-collagen interactions.
A nonlinear constituent based viscoelastic model for articular cartilage and analysis of tissue remodeling due to altered glycosaminoglycan-collagen interactions.
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基于非线性成分的关节软骨粘弹性模型以及由于糖胺聚糖-胶原蛋白相互作用改变而导致的组织重塑分析。
DOI：
10.1115/1.3192139
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Klisch,StephenM
中科院分区：
文献类型：
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作者：
Thomas,GregoryC;Asanbaeva,Anna;Vena,Pasquale;Sah,RobertL;Klisch,StephenM
基于组分的非线性粘弹性（VE）模型从先前的研究（Vena等人，2006年，“韧带非线性粘弹性行为的基于成分的模型”，J. Biomech。工程师：128，pp. 449-457），以使用关节软骨（AC）特有的可压缩弹性应力本构方程来并入糖胺聚糖（GAG）-胶原（COL）应力平衡。对于单轴加载的混合物的准线性VE成分，时间常数和弛豫比方程推导出突出的混合物的成分具有不同的准线性VE属性是一种机制，产生非线性VE组织。用胍去除GAG前后的新生牛AC标本进行单轴拉伸实验。实验组织VE参数直接从应力松弛数据计算，而内在COL VE参数通过曲线拟合的数据与非线性VE模型与内在GAG粘弹性忽略。选择组织和内在COL VE参数显着不同的对照组和实验组，并与GAG含量，表明存在GAG-COL相互作用，以调节组织和COL的机械性能。比较这项研究和其他对更成熟的AC组织进行GAG耗尽处理的研究的结果表明，GAG与COL网络的相互作用方式可能有利于发育生长期间的快速体积膨胀，同时保护细胞免受过量基质菌株的影响。此外，潜在的GAG-COL相互作用似乎随着组织成熟而减少，表明发育生长期间的独特重塑反应。
A constituent based nonlinear viscoelastic (VE) model was modified from a previous study (Vena, et al., 2006, “A Constituent-Based Model for the Nonlinear Viscoelastic Behavior of Ligaments,” J. Biomech. Eng., 128, pp. 449–457) to incorporate a glycosaminoglycan (GAG)-collagen (COL) stress balance using compressible elastic stress constitutive equations specific to articular cartilage (AC). For uniaxial loading of a mixture of quasilinear VE constituents, time constant and relaxation ratio equations are derived to highlight how a mixture of constituents with distinct quasilinear VE properties is one mechanism that produces a nonlinear VE tissue. Uniaxial tension experiments were performed with newborn bovine AC specimens before and afterandGAG depletion treatment with guanidine. Experimental tissue VE parameters were calculated directly from stress relaxation data, while intrinsic COL VE parameters were calculated by curve fitting the data with the nonlinear VE model with intrinsic GAG viscoelasticity neglected. Select tissue and intrinsic COL VE parameters were significantly different from control and experimental groups and correlated with GAG content, suggesting that GAG-COL interactions exist to modulate tissue and COL mechanical properties. Comparison of the results from this and other studies that subjected more mature AC tissue to GAG depletion treatment suggests that the GAGs interact with the COL network in a manner that may be beneficial for rapid volumetric expansion during developmental growth while protecting cells from excessive matrix strains. Furthermore, the underlying GAG-COL interactions appear to diminish as the tissue matures, indicating a distinctive remodeling response during developmental growth.