Syntheses of macrocyclic enzyme models. 7. Octopus cyclophanes having L-aspartate residues as novel water-soluble hosts; aggregation behavior and induced-fit molecular recognition
Syntheses of macrocyclic enzyme models. 7. Octopus cyclophanes having L-aspartate residues as novel water-soluble hosts; aggregation behavior and induced-fit molecular recognition
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DOI：
10.1021/ja00177a031
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发表时间：
1990-10
影响因子：
15
通讯作者：
Y. Murakami;J. Kikuchi;T. Ohno;O. Hayashida;M. Kojima
中科院分区：
文献类型：
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作者：
Y. Murakami;J. Kikuchi;T. Ohno;O. Hayashida;M. Kojima
我们现在制备了各自具有L-天冬氨酸残基1和2的章鱼环番。引入手性分子组分作为连接器单元，插入作为章鱼体的四氮杂-[3.3.3.3]对环芳骨架和作为疏水臂的烃分支之间。在这篇文章中，我们报告了它们在水介质中的聚集行为和独特的客体结合行为，重点是首次成功观察到诱导拟合主客体络合的动力学特征
We now prepared octopus cyclophanes each having L-aspartate residues, 1 and 2. The chiral molecular components were introduced as connector units, interposed between a tetraaza-[3.3.3.3] paracyclophane skeleton as an octopus body and hydrocarbon branches as hydrophobic arms. In this article, we report on their aggregation behavior and unique guest-binding behavior in aqueous media with emphasis on the first successful observations of dynamic features of induced-fit host-guest complexation