Premotor transcranial direct current stimulation (tDCS) affects primary motor excitability in humans
Premotor transcranial direct current stimulation (tDCS) affects primary motor excitability in humans
复制标题
DOI：
10.1111/j.1460-9568.2008.06090.x
复制
发表时间：
2008-03-01
影响因子：
3.4
通讯作者：
Nitsche, Michael A.
中科院分区：
文献类型：
--
作者：
Boros, Klara;Poreisz, Csaba;Nitsche, Michael A.
最近的研究表明，重复经颅磁刺激（rTMS）的前运动皮层（PM）修改同侧初级运动皮层（M1）的兴奋性。经颅直流电刺激（tDCS）是一种无创性诱导人类神经可塑性的新方法。tDCS直接在电极下的皮层区域产生神经可塑性，但也可能在远处的大脑区域诱导效应，这是由相互连接的区域的活动调制引起的。然而，这尚未进行电生理测试。我们的目的是研究运动前区tDCS是否可以通过皮质-皮质连接改变同侧M1的兴奋性。16名受试者接受了PM的阴极和阳极tDCS，8名受试者接受了背外侧前额叶皮层的tDCS。运动前阳极，而不是运动前阴极或前额tDCS，修改选择性短皮层内抑制/皮层内促进（SICI/ICF），而运动阈值，单测试脉冲运动诱发电位和输入-输出曲线在整个实验中是稳定的。具体而言，阳极tDCS减少皮质内抑制和增加成对脉冲兴奋性。运动前区tDCS对同侧M1皮质内兴奋性的选择性影响表明tDCS对远程皮质区的连接驱动效应。此外，这一发现间接证实了tDCS调节运动前兴奋性的功效，这可能对伴有病理性运动前活动的疾病的应用感兴趣。
Recent studies have shown that repetitive transcranial magnetic stimulation (rTMS) over the premotor cortex (PM) modifies the excitability of the ipsilateral primary motor cortex (M1). Transcranial direct current stimulation (tDCS) is a new method to induce neuroplasticity in humans non-invasively. tDCS generates neuroplasticity directly in the cortical area under the electrode, but might also induce effects in distant brain areas, caused by activity modulation of interconnected areas. However, this has not yet been tested electrophysiologically. We aimed to study whether premotor tDCS can modify the excitability of the ipsilateral M1 via cortico-cortical connectivity. Sixteen subjects received cathodal and anodal tDCS of the PM and eight subjects of the dorsolateral prefrontal cortex. Premotor anodal, but not premotor cathodal or prefrontal tDCS, modified selectively short intracortical inhibition/intracortical facilitation (SICI/ICF), while motor thresholds, single test-pulse motor-evoked potential and input-output curves were stable throughout the experiments. Specifically, anodal tDCS decreased intracortical inhibition and increased paired-pulse excitability. The selective influence of premotor tDCS on intracortical excitability of the ipsilateral M1 suggests a connectivity-driven effect of tDCS on remote cortical areas. Moreover, this finding indirectly substantiates the efficacy of tDCS to modulate premotor excitability, which might be of interest for applications in diseases accompanied by pathological premotor activity.