Non-invasive methods of diagnosis of endometriosis
Non-invasive methods of diagnosis of endometriosis
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DOI：
10.1097/00001703-200312000-00011
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发表时间：
2003-12-01
影响因子：
2.1
通讯作者：
Brosens, J
中科院分区：
文献类型：
--
作者：
Brosens, I;Puttemans, P;Brosens, J
腹腔镜检查是诊断子宫内膜异位症的金标准，但对疾病的视觉证据的需要是一个主要的绊脚石，无论是有效的临床管理受影响的患者，以及研究到这种常见的和衰弱的生殖疾病。腹腔镜检查是侵入性的，通常会导致诊断和治疗的延迟，特别是在有症状的青少年和年轻女性中。此外，骨盆的目视检查有很大的局限性，特别是对于腹膜后病变的诊断。因此，这并不奇怪，正在作出相当大的努力，以改善成像技术和评估潜在的分子标记物的疾病的诊断价值。最近的findingsHigh-resolution transvaginal ultrasound，在选定的情况下，磁共振成像提高腹膜后盆腔子宫内膜异位症的诊断以及涉及盆腔器官的病变的识别。各种血清和子宫内膜标志物正在评估其诊断潜力，特别是在子宫内膜异位症相关不孕症。第一个基因分析研究显示出积极的结果和蛋白质组学技术正在应用于确定新的诊断蛋白质表达patterns.SummaryCurrent成像技术，如经阴道超声检查，是有用的屏幕盆腔腹膜后子宫内膜异位症的存在，但未能诊断腹膜病变，小卵巢腺瘤和粘连。后基因组技术和新的血清和子宫内膜标志物的鉴定可能会彻底改变未来子宫内膜异位症的诊断。
Purpose of reviewLaparoscopy is the gold standard for the diagnosis of endometriosis but the need for visual evidence of the disease is a major stumbling-block for both effective clinical management of affected patients as well as for research into this common and debilitating reproductive disease. Laparoscopy is invasive and often causes a delay in diagnosis and treatment, especially in symptomatic teenagers and young women. Moreover, the visual inspection of the pelvis has major limitations, particularly for the diagnosis of retroperitoneal lesions. It is therefore not surprising that considerable efforts are being made to improve imaging techniques and to evaluate the diagnostic value of potential molecular markers of disease.Recent findingsHigh-resolution transvaginal ultrasonography and, in selected cases, magnetic resonance imaging improve the diagnosis of retroperitoneal pelvic endometriosis as well as the identification of lesions that involve pelvic organs. A variety of serum and endometrial markers are being evaluated for their diagnostic potential, particularly in endometriosis associated infertility. The first gene profiling studies are showing positive results and proteomic technology is being applied to identify novel diagnostic protein expression patterns.SummaryCurrent imaging techniques, such as transvaginal ultrasonography, are useful to screen the pelvis for the presence of retroperitoneal endometriosis but fail to diagnose peritoneal lesions, small ovarian endometriomas and adhesions. Postgenomic technologies and identification of novel serum and endometrial markers are likely to revolutionize future diagnosis of endometriosis.