Role of dopamine transporter genotype and maternal prenatal smoking in childhood hyperactive-impulsive, inattentive, and oppositional behaviors
Role of dopamine transporter genotype and maternal prenatal smoking in childhood hyperactive-impulsive, inattentive, and oppositional behaviors
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DOI：
10.1016/s0022-3476(03)00208-7
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发表时间：
2003-07-01
影响因子：
5.1
通讯作者：
Lanphear, BP
中科院分区：
文献类型：
--
作者：
Kahn, RS;Khoury, J;Lanphear, BP
目的探讨多巴胺转运体(DAT)基因多态性与母亲产前吸烟对儿童多动、冲动和注意力不集中的联合影响。主要结果是康纳斯父母评定量表修订版(CPRS R：L)中的DSM-IV多动-冲动和注意力不集中量表。一个次要的结果是对立的规模。预测因素包括DAT基因和母亲产前吸烟报告。结果在多因素分析中，产前吸烟和DAT+/+基因携带者的多动-冲动得分显著升高(β，7.5；SE，2.9；P
Objective To examine the joint effects of a dopamine transporter (DAT) polymorphism and maternal prenatal smoking on childhood hyperactivity-impulsivity and inattentiveness.Study design A cohort of 161 children was followed prospectively from age 6 months to 60 months. Primary outcomes were the DSM-IV hyperactive-impulsive and inattentive scales of the Conners' Parent Rating Scale Revised-Long Version (CPRS R:L). A secondary outcome was the oppositional scale. Predictors included DAT genotype and maternal report of prenatal smoking. Children homozygous for the 480-bp DAT allele (DAT +/+) were compared with all other children (DAT +/- or -/-).Results In multivariate analyses, children with both prenatal smoke exposure and the DAT +/+ genotype had significantly elevated hyperactive-impulsive scores (beta, 7.5; SE, 2.9; P