Cigarette smoking is associated with suicidality in bipolar disorder.
Cigarette smoking is associated with suicidality in bipolar disorder.
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吸烟与躁郁症患者的自杀行为有关。
DOI：
10.1111/j.1399-5618.2009.00744.x
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发表时间：
2009
影响因子：
5.4
通讯作者：
Simon,NaomiM
中科院分区：
文献类型：
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作者：
Ostacher,MichaelJ;Lebeau,RichardT;Perlis,RoyH;Nierenberg,AndrewA;Lund,HannahG;Moshier,SamanthaJ;Sachs,GaryS;Simon,NaomiM
目的：双相情感障碍患者的吸烟与自杀行为有关，尽管两者之间的确切关系尚不清楚。方法：在对116名双相情感障碍患者进行的前瞻性观察研究中，我们通过Linehan自杀行为问卷（SBQ）和9个月内的前瞻性自杀企图来研究吸烟与自杀行为之间的关系。冲动测量Barratt Impulsivity Scale.Results：吸烟与较高的基线SBQ分数在单变量和调整分析，但在回归模型中的冲动统计调整后并不显着。基线时吸烟者在随访期间自杀企图的比例（5/31，16.1%）高于非吸烟者（3/85，3.5%）; p = 0.031，比值比= 5.25（95%置信区间：1.2-23.5）。 在基线吸烟也显着预测较高的SBQ score at nine months.Conclusions：在这项研究中，目前的吸烟是一个预测器的当前和9个月的自杀意念和行为的双相情感障碍，它很可能是冲动占了一些这种关系。
Objectives:Cigarette smoking in individuals with bipolar disorder has been associated with suicidal behavior, although the precise relationship between the two remains unclear.Methods:In this prospective observational study of 116 individuals with bipolar disorder, we examined the association between smoking and suicidality as measured by Linehan’s Suicide Behaviors Questionnaire (SBQ) and prospective suicide attempts over a nine‐month period. Impulsivity was measured by the Barratt Impulsiveness Scale.Results:Smoking was associated with higher baseline SBQ scores in univariate and adjusted analyses, but was not significant after statistical adjustment for impulsivity in a regression model. A higher proportion of smokers at baseline made a suicide attempt during the follow‐up period (5/31, 16.1%) compared to nonsmokers (3/85, 3.5%); p = 0.031, odds ratio = 5.25 (95% confidence interval: 1.2–23.5). Smoking at baseline also significantly predicted higher SBQ score at nine months.Conclusions:In this study, current cigarette smoking was a predictor of current and nine‐month suicidal ideation and behavior in bipolar disorder, and it is likely that impulsivity accounts for some of this relationship.