Evaluation of a projection-domain lung nodule insertion technique in thoracic CT.
Evaluation of a projection-domain lung nodule insertion technique in thoracic CT.
复制标题
胸部 CT 投影域肺结节插入技术的评估。
DOI：
10.1117/12.2217009
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
Yu,Lifeng
中科院分区：
文献类型：
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作者：
Ma,Chi;Chen,Baiyu;Koo,ChiWan;Takahashi,EdwinA;Fletcher,JoelG;McCollough,CynthiaH;Levin,DavidL;Kuzo,RonaldS;Viers,LyndsayD;Sheldon,StephanieAVincent;Leng,Shuai;Yu,Lifeng
基于任务的计算机断层扫描（CT）图像质量评估需要大量的情况下，地面真相。将病变插入现有病例以模拟阳性病例是一种有前途的替代方法。本研究的目的是评价最近开发的基于原始数据的胸部CT病变插入技术。从患者CT图像中分割肺部病变，向前投影，并重新插入相同的患者CT投影数据。21例CT扫描共分割出32个不同密度的结节。两名经验丰富的放射科医生和两名对该过程不知情的住院医生在两项子研究中独立评价了这些插入的结节。首先，以随机顺序呈现32个插入的结节和32个原始结节，每个结节的评分为1 - 10（1=绝对人工，10=绝对真实）。其次，将插入的病变和相应的原始病变并排呈现给每位阅片人，阅片人识别插入的病变并提供置信度评分（1=无置信度至5=完全确定）。对于随机评价，真实的与人工结节的区分度较差，2名放射科医师、2名住院医师和所有4名阅片者的受试者手术特征曲线下面积分别为0.69（95% CI：0.58-0.78）、0.57（95% CI：0.46-0.68）和0.62（95% CI：0.54-0.69）。对于并行评价，尽管所有4名阅片师均正确识别了103/128对插入病变，但置信度评分为中等（2.6）。我们的基于投影域的肺结节插入技术提供了一种鲁棒的方法来人工生成临床病例，这些病例被证明难以与真实的病例区分开。
Task-based assessment of computed tomography (CT) image quality requires a large number of cases with ground truth. Inserting lesions into existing cases to simulate positive cases is a promising alternative approach. The aim of this study was to evaluate a recently-developed raw-data based lesion insertion technique in thoracic CT. Lung lesions were segmented from patient CT images, forward projected, and reinserted into the same patient CT projection data. In total, 32 nodules of various attenuations were segmented from 21 CT cases. Two experienced radiologists and 2 residents blinded to the process independently evaluated these inserted nodules in two sub-studies. First, the 32 inserted and the 32 original nodules were presented in a randomized order and each received a rating score from 1 to 10 (1=absolutely artificial to 10=absolutely realistic). Second, the inserted and the corresponding original lesions were presented side-by-side to each reader, who identified the inserted lesion and provided a confidence score (1=no confidence to 5=completely certain). For the randomized evaluation, discrimination of real versus artificial nodules was poor with areas under the receiver operative characteristic curves being 0.69 (95% CI: 0.58–0.78), 0.57 (95% CI: 0.46–0.68), and 0.62 (95% CI: 0.54–0.69) for the 2 radiologists, 2 residents, and all 4 readers, respectively. For the side-by-side evaluation, although all 4 readers correctly identified inserted lesions in 103/128 pairs, the confidence score was moderate (2.6). Our projection-domain based lung nodule insertion technique provides a robust method to artificially generate clinical cases that prove to be difficult to differentiate from real cases.