The role of human papillomavirus in cervical adenocarcinoma carcinogenesis
The role of human papillomavirus in cervical adenocarcinoma carcinogenesis
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DOI：
10.1016/s0959-8049(00)00376-2
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发表时间：
2001-01-01
影响因子：
8.4
通讯作者：
Wilander, E
中科院分区：
文献类型：
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作者：
Andersson, S;Rylander, E;Wilander, E
人乳头瘤病毒（HPV）被认为是宫颈鳞状细胞癌发展中最重要的辅助因子。宫颈腺癌也与HPV有关，但据报道相关性不太明显。在本研究中，通过瑞典癌症登记处确定了131例宫颈腺癌，进行了形态学检查，然后用敏感的聚合酶链反应（PCR）为基础的HPV方法进行了分析，以研究与年龄相关的HPV患病率。在仅PCR扩增HPV L1基因后，在64%的肿瘤中鉴定出HPV，在PCR扩增HPV的L1和E6基因后，在71%的肿瘤中鉴定出HPV。HPV 18是最普遍的（52%），其次是HPV 16（33%）和其他类型的HPV（15%）。HPV的感染率与年龄有关。在40岁以下的女性中，HPV感染率为89%，而在60岁及以上的女性中，HPV感染率仅为43%。差异有统计学意义，P < 0.005。HPV阳性腺癌的年龄分布与宫颈鳞状细胞癌相似，最大年龄在40-49岁组，而HPV阴性腺癌的频率随年龄增加，这是老年妇女中发生的大多数癌症的典型特征。(C)2001爱思唯尔科技有限公司版权所有。
Human papillomavirus (HPV) is considered the single most important co-factor in the development of cervical squamous cell carcinomas. Adenocarcinomas of the cervix are also related to HPV, but the correlation is reported to be less pronounced. In the present study, 131 cervical adenocarcinomas were identified through the Swedish Cancer Registry, examined morphologically and then analysed with sensitive polymerase chain reaction (PCR)-based HPV methods for a study of age-related prevalence of HPV. HPV was identified in 64% of the tumours after PCR amplification of the HPV L1 gene only and in 71% following PCR amplification of both the L1 and E6 genes of HPV. HPV 18 was the most prevalent (52%), followed by HPV 16 (33%) and other types of HPV (15%). The prevalence of HPV was shown to be age-dependent. In women younger than 40 years, HPV was present in 89%, whereas in women 60 years and older, HPV was observed in only 43%. The difference was statistically significant, P < 0.005. The HPV-positive adenocarcinomas were represented by an age distribution similar to that of cervical squamous carcinomas with a maximum age, in the 40-49 year old group, whereas the frequency of HPV-negative adenocarcinomas increased with age, typical of most carcinomas occurring in elderly women. (C) 2001 Elsevier Science Ltd. All rights reserved.