Treadmill training does not enhance skeletal muscle recovery following disuse atrophy in older male mice.
Treadmill training does not enhance skeletal muscle recovery following disuse atrophy in older male mice.
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DOI：
10.3389/fphys.2023.1263500
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发表时间：
2023
影响因子：
4
通讯作者：
中科院分区：
文献类型：
--
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衰老的一个标志是废用性萎缩后肌肉恢复不良。有效的策略，以提高肌肉恢复后废用性萎缩的老化是不存在的。先前的运动训练可以导致有利的肌肉形态和细胞适应，从而促进肌肉在衰老过程中的恢复。在这里，我们描述了运动训练对老年雄性小鼠骨骼肌炎症和代谢特征、细胞重塑和功能的影响，以及在废用性萎缩恢复前后的股动脉反应性。我们假设，在老年雄性小鼠中进行12周的跑步机训练可以改善骨骼肌细胞在基线和废用性萎缩恢复期间的重塑，从而改善肌肉再生。方法：对老年运动训练小鼠和久坐小鼠的身体表现、离体肌肉和血管功能、组织和器官质量、后肢肌肉细胞重塑（巨噬细胞、卫星细胞、毛细血管、肌纤维大小和纤维化）以及蛋白质水解、炎症和代谢肌肉转录物进行评估。结果：我们发现在运动训练后的基线（与久坐小鼠相比），运动能力和身体功能增加，脂肪量减少，内皮功能改善。然而，运动训练并没有改变胫骨前肌或腓肠肌的转录谱、巨噬细胞、卫星细胞、毛细血管或胶原含量或肌纤维大小，只倾向于在废用性萎缩恢复期间增加胫骨质量。结论：虽然老年雄性小鼠的运动训练如预期的那样改善了内皮功能、身体表现和全身组织组成，但12周的跑步机训练对基线骨骼肌重塑或废用性萎缩后恢复的影响有限。
Introduction: A hallmark of aging is poor muscle recovery following disuse atrophy. Efficacious strategies to enhance muscle recovery following disuse atrophy in aging are non-existent. Prior exercise training could result in favorable muscle morphological and cellular adaptations that may promote muscle recovery in aging. Here, we characterized the impact of exercise training on skeletal muscle inflammatory and metabolic profiles and cellular remodeling and function, together with femoral artery reactivity prior to and following recovery from disuse atrophy in aged male mice. We hypothesized that 12 weeks of treadmill training in aged male mice would improve skeletal muscle cellular remodeling at baseline and during recovery from disuse atrophy, resulting in improved muscle regrowth. Methods: Physical performance, ex vivo muscle and vascular function, tissue and organ mass, hindlimb muscle cellular remodeling (macrophage, satellite cell, capillary, myofiber size, and fibrosis), and proteolytic, inflammatory, and metabolic muscle transcripts were evaluated in aged exercise-trained and sedentary mice. Results: We found that at baseline following exercise training (vs. sedentary mice), exercise capacity and physical function increased, fat mass decreased, and endothelial function improved. However, exercise training did not alter tibialis anterior or gastrocnemius muscle transcriptional profile, macrophage, satellite cell, capillarity or collagen content, or myofiber size and only tended to increase tibialis mass during recovery from disuse atrophy. Conclusion: While exercise training in old male mice improved endothelial function, physical performance, and whole-body tissue composition as anticipated, 12 weeks of treadmill training had limited impact on skeletal muscle remodeling at baseline or in response to recovery following disuse atrophy.
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DOI：
10.1096/fj.202100883r
发表时间：
2021-09
期刊：
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
影响因子：
--
作者：
Petrocelli JJ;Mahmassani ZS;Fix DK;Montgomery JA;Reidy PT;McKenzie AI;de Hart NM;Ferrara PJ;Kelley JJ;Eshima H;Funai K;Drummond MJ
通讯作者：
Drummond MJ
影响因子：
10.8
作者：
Cho, Jae Min;Park, Seul-Ki;Symons, J. David
通讯作者：
Symons, J. David
影响因子：
3.3
作者：
Brooks, Matthew J.;Hajira, Ameena;Alway, Stephen E.
通讯作者：
Alway, Stephen E.
DOI：
10.1093/function/zqac027
发表时间：
2022
期刊：
Function (Oxford, England)
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1152/ajpendo.00422.2018
发表时间：
2019-07-01
影响因子：
5.1
作者：
Reidy, Paul T.;McKenzie, Alec, I;Drummond, Micah J.
通讯作者：
Drummond, Micah J.