Left ventricular diastolic filling in young persons with type 1 diabetes mellitus.
Left ventricular diastolic filling in young persons with type 1 diabetes mellitus.
复制标题
DOI:
10.5507/bp.2003.008
复制
发表时间:
2003-10-01
期刊:
影响因子:
--
通讯作者:
Salinger, Jiri
中科院分区:
文献类型:
--
作者:
Berkova, Marie;Opavsky, Jaroslav;Salinger, Jiri
The purpose of this study was to evaluate the influence of diabetes mellitus on left ventricular function. Using Doppler echocardiography we examined a group of 49 young (20-32 years old) persons with type 1 diabetes mellitus and a group of healthy age-matched men and evaluated the parameters of diastolic filling of the left ventricle (LV). We found significant differences in peak velocity of early filling of the left ventricle ((70.07+-10.84 vers. 78.2+-10.59 cm.s-1, p+-0.01), peak velocity of late diastolic filling of LV (A=47.74+-11.6 vers. 43.15+-7.48 cm.s-1, pltoreq0.027), ratio E/A (1.53+-0.4 vers. 1.84+-0.33), time velocity integral of peak E (TVIE=0.083+-0.014 vers. 0.1+-0.022m, pltoreq0.001), time velocity integral of peak A (TVIA=0.039+-0.011 vers. 0.037+-0.012m, pltoreq0.3), ratio TVIE/TVIA (2.3+-0.73 vers. 2.9+-0.9, pltoreq0.002), time E (204.4+-31.59 vers. 198.4+-19.09 ms, pltoreq0.27), time A (126.9ltoreq23.0 vers. 113.5+-15.59 ms, pltoreq0.002), time E/time A (1.64+-0.3 vers. 1.76+-0.22, pltoreq0.039) and duration of isovolumic relaxation period (IVRT=88.2+-10.8 vers. 71.13+-8.4 ms, pltoreq0.0001). Despite significant differences all the results were in the range of values for the healthy population. However in detailed analysis we found that the values measured in young (20-32 years old) persons with type 1 diabetes mellitus corresponded with diastolic parameters of healthy men of the age of 50 years and more. Thus, diabetes mellitus can influence the relaxation properties of the left ventricle.