Left ventricular diastolic filling in young persons with type 1 diabetes mellitus.

Left ventricular diastolic filling in young persons with type 1 diabetes mellitus.
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DOI:
10.5507/bp.2003.008
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发表时间:
2003-10-01
期刊:
Biomedical Papers (Olomouc)
影响因子:
--
通讯作者:
Salinger, Jiri
Salinger, Jiri
中科院分区:
其他
文献类型:
--
作者:
Berkova, Marie;Opavsky, Jaroslav;Salinger, Jiri

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本研究的目的是评估糖尿病对左心室功能的影响。我们使用多普勒超声心动图检查了一组 49 名患有 1 型糖尿病的年轻人(20-32 岁)和一组年龄匹配的健康男性,并评估了左心室 (LV) 舒张期充盈参数。我们发现左心室早期充盈峰值速度((70.07+-10.84 与 78.2+-10.59 cm.s-1,p+-0.01)、左心室舒张晚期充盈峰值速度(A=47.74+-11.6 与 43.15+-7.48 cm.s-1, pltoreq0.027), 比率 E/A (1.53+-0.4 相对于 1.84+-0.33),峰值 E 的时间速度积分 (TVIE=0.083+-0.014 相对于 0.1+-0.022m,pltoreq0.001),峰值 A 的时间速度积分 (TVIA=0.039+-0.011 相对于 0.1+-0.022m,pltoreq0.001) 0.037+-0.012m, pltoreq0.3),TVIE/TVIA 比率(2.3+-0.73 与 2.9+-0.9,pltoreq0.002),时间 E(204.4+-31.59 与 198.4+-19.09 ms,pltoreq0.27),时间 A(126.9ltoreq23.0 与 2.9+-0.9,pltoreq0.002) 113.5+-15.59 毫秒,pltoreq0.002), 时间 E/时间 A(1.64+-0.3 对比 1.76+-0.22,pltoreq0.039)和等容舒张期持续时间(IVRT=88.2+-10.8 对比 71.13+-8.4 ms,pltoreq0.0001)。尽管存在显着差异,但所有结果均在健康人群的值范围内。然而,在详细分析中我们发现测量值 年轻(20-32岁)1型糖尿病患者的舒张压参数与50岁及以上健康男性的舒张压参数相对应。因此,糖尿病会影响左心室的舒张特性。
The purpose of this study was to evaluate the influence of diabetes mellitus on left ventricular function. Using Doppler echocardiography we examined a group of 49 young (20-32 years old) persons with type 1 diabetes mellitus and a group of healthy age-matched men and evaluated the parameters of diastolic filling of the left ventricle (LV). We found significant differences in peak velocity of early filling of the left ventricle ((70.07+-10.84 vers. 78.2+-10.59 cm.s-1, p+-0.01), peak velocity of late diastolic filling of LV (A=47.74+-11.6 vers. 43.15+-7.48 cm.s-1, pltoreq0.027), ratio E/A (1.53+-0.4 vers. 1.84+-0.33), time velocity integral of peak E (TVIE=0.083+-0.014 vers. 0.1+-0.022m, pltoreq0.001), time velocity integral of peak A (TVIA=0.039+-0.011 vers. 0.037+-0.012m, pltoreq0.3), ratio TVIE/TVIA (2.3+-0.73 vers. 2.9+-0.9, pltoreq0.002), time E (204.4+-31.59 vers. 198.4+-19.09 ms, pltoreq0.27), time A (126.9ltoreq23.0 vers. 113.5+-15.59 ms, pltoreq0.002), time E/time A (1.64+-0.3 vers. 1.76+-0.22, pltoreq0.039) and duration of isovolumic relaxation period (IVRT=88.2+-10.8 vers. 71.13+-8.4 ms, pltoreq0.0001). Despite significant differences all the results were in the range of values for the healthy population. However in detailed analysis we found that the values measured in young (20-32 years old) persons with type 1 diabetes mellitus corresponded with diastolic parameters of healthy men of the age of 50 years and more. Thus, diabetes mellitus can influence the relaxation properties of the left ventricle.