Effect of exercise on stability of chronically enlarged motor units
Effect of exercise on stability of chronically enlarged motor units
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运动对长期增大的运动单位稳定性的影响
DOI：
10.1002/mus.10057
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发表时间：
2002
期刊：
影响因子：
3.4
通讯作者：
Tessa Gordon
中科院分区：
文献类型：
--
作者：
S. L. Tam;V. Archibald;N. Tyreman;Tessa Gordon
慢性去神经综合征（如脊髓灰质炎后综合征）与运动神经元死亡后进行性肌无力和疲劳相关。这些综合征的病因和治疗都不清楚。为了解决这个问题，我们部分去神经大鼠后肢肌肉1或12个月，并检查是否慢性扩大的运动单位（MU）变得不稳定，随着时间的推移，并进一步不稳定，每天运行的练习轮。与1个月时的结果相比，在12个月时，广泛失神经支配肌肉的电生理学和形态学测量的MU增大显著减少，中度失神经支配肌肉的程度较小。1个月的跑步锻炼进一步减少了广泛失神经肌肉中慢性增大的MU的大小。因此，我们（1）成功建立了一个与时间相关的MU大小减小的大鼠模型，其中慢性增大的MU的不稳定导致轴突终末的丢失，以及（2）证明了非生理活动具有进一步使慢性增大的MU不稳定的小但显著的影响。肌肉神经25：000-000，2002 DOI 10.1002/mus.10057
Chronic denervation syndromes such as the post‐polio syndrome are associated with progressive muscle weakness and fatigue after motoneuron death. Neither the etiology nor the management of these syndromes is clear. To address this issue, we partially denervated rat hindlimb muscles for 1 or 12 months and examined whether chronically enlarged motor units (MUs) become destabilized with time and further destabilized by daily running on exercise wheels. MU enlargement, measured electrophysiologically and morphologically was significantly reduced at 12 months in extensively denervated muscles, and to a lesser extent in moderately denervated muscles, as compared to the findings at 1 month. A 1‐month period of running exercise further reduced the size of the chronically enlarged MUs in the extensively denervated muscles. We have therefore (1) successfully established a rat model of time‐related MU size reduction, in which destabilization of chronically enlarged MUs results in loss of axonal terminals, and (2) demonstrated that nonphysiological activity has small but significant effects of further destabilizing the chronically enlarged MUs. © 2002 Wiley Periodicals, Inc. Muscle Nerve 25: 000–000, 2002 DOI 10.1002/mus.10057
部分去神经支配小鼠肌肉的神经支配形态的年龄差异。
DOI：
10.1523/jneurosci.10-05-01530.1990
发表时间：
1990
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Jacob,JM;Robbins,N
通讯作者：
Robbins,N
影响因子：
--
作者：
Lange,DJ;Smith,T;Lovelace,RE
通讯作者：
Lovelace,RE