Effects of blackcurrant extract on arterial functions in older adults: A randomized, double-blind, placebo-controlled, crossover trial
Effects of blackcurrant extract on arterial functions in older adults: A randomized, double-blind, placebo-controlled, crossover trial
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DOI：
10.1080/10641963.2020.1764015
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发表时间：
2020-05
影响因子：
12.3
通讯作者：
T. Okamoto;Yuto Hashimoto;Ryota Kobayashi;K. Nakazato;M. Willems
中科院分区：
文献类型：
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作者：
T. Okamoto;Yuto Hashimoto;Ryota Kobayashi;K. Nakazato;M. Willems
摘要 目的 黑加仑提取物主要含有花青素。一些报告表明花青素对心血管功能具有有益作用。本研究的目的是检查 7 天摄入新西兰黑加仑 (NZBC) 提取物对动脉功能的影响，例如动脉功能。动脉硬化和血脂。方法 进行了一项随机、双盲、安慰剂对照、交叉设计研究，清除期为 28 天。 14 名老年人参与了这项研究（年龄 73.3 ± 1.7 岁）。参与者服用为期 7 天的安慰剂疗程或两粒 NZBC 提取物胶囊（每粒 300 毫克胶囊含有 35% 的黑加仑提取物）。参与者首先进行两项试验中的一项，然后在洗脱期后进行另一项试验。在基线时测量颈动脉-股动脉脉搏波速度、中心动脉僵硬度指数和中心血压，并在 7 天研究期结束时再次测量。结果 与基线相比，服用 NZBC 的 7 天研究期后，颈动脉-股动脉脉搏波速度 (P = .03) 和中心血压 (P = .02) 显着下降。此外，NZBC 摄入试验中颈动脉-股动脉脉搏波速度 (P = .04) 和中心血压 (P = .001) 比安慰剂摄入试验中显着下降。未观察到对血脂的影响。结论 这些结果表明，短期 NZBC 摄入可降低老年人的中央动脉僵硬度和中央血压。因此，富含花青素的黑加仑可能有利于维持或改善心血管健康，作为药物的替代品。缩写 Aix：增强指数； BP：血压； cfPWV：颈动脉-股动脉脉搏波速度； CVD：心血管疾病； DBP：舒张压； faPWV：股踝脉搏波速度； FG：空腹血糖； HDL：高密度脂蛋白胆固醇； LDL：低密度脂蛋白胆固醇； MBP：平均血压； NZBC：新西兰黑加仑； PP：脉冲压力； SBP：收缩压； TG：甘油三酯。
ABSTRACT Purpose Blackcurrant extract mainly contains anthocyanins. Several reports suggest that anthocyanins have beneficial effect for cardiovascular functions. The aim of this study was to examine the effect of 7-day intake of New Zealand blackcurrant (NZBC) extract on arterial functions, e.g. arterial stiffness, and serum lipids. Methods A randomized, double-blind, placebo-controlled, crossover design study with a washout period of 28 days was conducted. Fourteen older adults participated in this study (age 73.3 ± 1.7 years). Participants took either a 7-day course of placebo or two capsules of NZBC extract (each 300 mg capsule contains 35% blackcurrant extract). Participants took one of the two trials first and then took the other after a washout period. Carotid-femoral pulse-wave velocity, an index of central arterial stiffness, and central blood pressure were measured at baseline and again at the end of the 7-day study period. Results Compared to baseline, carotid-femoral pulse-wave velocity (P = .03) and central blood pressure (P = .02) decreased significantly after the 7-day study period with NZBC intake. In addition, carotid-femoral pulse-wave velocity (P = .04) and central blood pressure (P = .001) in the NZBC intake trial decreased significantly more than in the placebo intake trial. No effects were observed on serum lipids. Conclusion These results suggest that short-term NZBC intake reduces central arterial stiffness and central blood pressure in older adults. Therefore, anthocyanin-rich blackcurrants might be beneficial for maintaining or improving cardiovascular health as an alternative to pharmaceutical medications. Abbreviations Aix: augmentation index; BP: blood pressure; cfPWV: carotid–femoral pulse-wave velocity; CVD: cardiovascular diseases; DBP: diastolic blood pressure; faPWV: femoral-ankle pulse-wave velocity; FG: fasting glucose; HDL: high-density lipoprotein cholesterol; LDL: low-density lipoprotein cholesterol; MBP: mean blood pressure; NZBC: New Zealand blackcurrant; PP: pulse pressure; SBP: systolic blood pressure; TG: triglycerides.