Treadmill exercise prevents aging-induced failure of memory through an increase in neurogenesis and suppression of apoptosis in rat hippocampus
Treadmill exercise prevents aging-induced failure of memory through an increase in neurogenesis and suppression of apoptosis in rat hippocampus
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DOI：
10.1016/j.exger.2010.02.005
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发表时间：
2010-05-01
影响因子：
3.9
通讯作者：
Jee, Yong-Seok
中科院分区：
文献类型：
--
作者：
Kim, Sung-Eun;Ko, Il-Gyu;Jee, Yong-Seok
衰老会导致海马体功能发生变化。从而导致认知缺陷，例如记忆力衰退。海马齿状回的神经发生持续一生，但从成年早期开始逐渐下降。细胞凋亡在各种病理和生理条件下发生，细胞过度凋亡可导致人类多种功能障碍。海马细胞凋亡也会扰乱认知功能在这项研究中，我们检查了跑步机运动对记忆的影响，与老年大鼠海马齿状回神经发生和细胞凋亡有关。目前的结果表明，衰老导致的记忆丧失与海马齿状回神经发生减少和细胞凋亡增加有关。跑步机运动通过增强神经发生和抑制海马齿状回细胞凋亡来改善短期和空间记忆。老年大鼠脑回 在本研究中，我们表明跑步机运动是预防老年人记忆力衰退的一种非常有用的策略 (C) 2010 Elsevier Inc. 保留所有权利。
Aging leads to functional changes in the hippocampus. and consequently induces cognitive deficits, such as failure of memory. Neurogenesis in the hippocampal dentate gyrus continues throughout life, but steadily declines from early adulthood. Apoptosis occurs under various pathologic and physiologic conditions, and excessive apoptotic cell death can cause a number of functional disorders in humans. Apoptosis in the hippocampus also disturbs cognitive functions In this study, we examined the effect of treadmill exercise on memory in relation to neurogensis and apoptosis in the hippocampal dentate gyrus of old-aged rats The present results showed that loss of memory by aging was associated with a decrease in neurogenesis and an increase in apoptosis in the hippocampal dentate gyrus Treadmill exercise improved short-term and spatial memories by enhancing neurogenesis and suppressing apoptosis in the hippocampal dentate gyrus of old-aged rats In the present study, we showed that treadmill exercise is a very useful strategy for preventing failure of memory in the elderly (C) 2010 Elsevier Inc. All rights reserved.