A review and roadmap of the skin, lung and gut microbiota in systemic sclerosis.
A review and roadmap of the skin, lung and gut microbiota in systemic sclerosis.
复制标题
系统性硬化症中皮肤、肺和肠道微生物群的回顾和路线图。
DOI：
10.1093/rheumatology/keab262
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Cheng,Michelle
中科院分区：
文献类型：
--
作者：
Teaw,Shannon;Hinchcliff,Monique;Cheng,Michelle
随着我们对SSc的遗传基础的理解的增加，关于在遗传易感性个体中诱导和传播SSc的环境触发因素的问题出现了。环境、免疫系统和居住在患者皮肤和胃肠道的微生物物种之间的相互作用是SSc在很大程度上未被探索的病理生物学前沿。本文综述了SSc宿主与其微生物群之间关系的研究方法、实验研究结果和未来发展方向。
As our understanding of the genetic underpinnings of SSc increases, questions regarding the environmental trigger(s) that induce and propagate SSc in the genetically predisposed individual emerge. The interplay between the environment, the immune system, and the microbial species that inhabit the patient’s skin and gastrointestinal tract is a pathobiological frontier that is largely unexplored in SSc. The purpose of this review is to provide an overview of the methodologies, experimental study results and future roadmap for elucidating the relationship between the SSc host and his/her microbiome.