Evoked potential components unique to non-REM sleep: relationship to evoked K-complexes and vertex sharp waves
Evoked potential components unique to non-REM sleep: relationship to evoked K-complexes and vertex sharp waves
复制标题
DOI：
10.1016/s0167-8760(02)00117-4
复制
发表时间：
2002-12-01
影响因子：
3
通讯作者：
Colrain, IM
中科院分区：
文献类型：
--
作者：
Bastien, CH;Crowley, KE;Colrain, IM
在失去清醒意识后，对刺激的平均反应会产生诱发电位波形，其显著成分要么是非快速眼动睡眠所特有的，要么是被非快速眼动睡眠大大增强的。在睡眠开始阶段(阶段1)，这些是P2和N350。随着稳定睡眠的建立(阶段2和SWS)，N550和P900也是突出的。对与个体反应相关的脑电的研究表明，相当大比例的刺激会诱发K波或顶尖波(VSWs)，偶尔会同时诱发两者。最近的工作表明，平均反应中的N550是由于K-复合体的存在，而N350至少在很大程度上是由于VSWs的存在。这些图形元素的大小表明它们可能是由多个神经单位的同步放电产生的。两者都很容易在没有外部刺激的情况下观察到，并作为睡眠的正常组成部分出现，事实上，K-复合体被用作稳定的非快速眼动睡眠开始的识别特征之一。本综述详细介绍了这些特征及其相关的诱发电位成分的研究，包括刺激特征、与其产生相关的脑状态、头皮地形图以及随年龄的变化。(C)2002 Elsevier Science B.V.保留所有权利。
Following the loss of wakeful consciousness, the averaging of responses to stimuli produce evoked potential waveforms with prominent components either unique to or greatly enhanced by non-REM sleep. In the sleep onset periods (stage 1) these are the P2 and N350. Following the establishment of stable sleep (stage 2 and SWS), the N550 and P900 are also prominent. Investigation of the EEG associated with individual responses indicates that a good proportion of stimuli elicit, K-complexes or vertex sharp waves (VSWs) and occasionally will elicit both. Recent work has indicated that the N550 in the averaged response is due to the presence of K-complexes and that the N350 is at least largely due to the presence of VSWs. The large size of these grapho-elements indicates that they are probably produced by a synchronized discharge of multiple neural units. Both are readily observed in the absence of external stimulation and occur as normal components of sleep, indeed the K-complex is used as one of the identifying features of the onset of stable non-REM sleep. The present review details the investigation of these features and their associated evoked potential components, in terms of stimulus features, brain states associated with their production, their scalp topography, and changes as a function of age. (C) 2002 Elsevier Science B.V. All rights reserved.