RELIABILITY AND INTERRELATIONS AMONG SERUM SEX-HORMONES IN POSTMENOPAUSAL WOMEN
RELIABILITY AND INTERRELATIONS AMONG SERUM SEX-HORMONES IN POSTMENOPAUSAL WOMEN
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DOI：
10.1093/oxfordjournals.aje.a115801
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发表时间：
1991-01-01
影响因子：
5
通讯作者：
POWELL, JG
中科院分区：
文献类型：
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作者：
CAULEY, JA;GUTAI, JP;POWELL, JG
血清性激素可能与绝经后妇女患骨质疏松症、心脏病、乳腺癌和子宫内膜癌等多种疾病的风险有关。为了评估性激素与疾病的关系，测量应该是可靠的，有效的和实用的。在本文中，作者评价了1981-1986年在宾夕法尼亚州匹兹堡招募的绝经后白色妇女血清性激素的短期（4周）和长期（2年）可靠性以及血清性激素之间的相互关系。为了进行比较，作者同时评估了其他常用风险因素的短期和长期可靠性，即，血脂、脂蛋白和血压。雌酮，雌二醇，睾酮和雄烯二酮的血清浓度测定提取，柱层析，放射免疫法。通过计算组内相关系数（R）及其95%置信区间估计可靠性。大约50%的雌二醇水平低于测定的灵敏度，因此，应谨慎解释这些结果。睾酮的组内相关系数为0.92（95%置信区间为1.0-082），这表明一个单一的措施可能是可靠的，在描述妇女的流行病学研究。超过4周，雌酮可以更可靠地测量（R = 0.72）比超过2年（R = 0.56），但在长期的变异性是类似于观察到的其他生物变量，这表明，在雌酮和疾病之间的关系是相当可观的情况下，可以使用一个单一的措施。对于雌二醇和雄烯二酮，组内相关性很小，表明重现性差，需要更多的测量。雌酮浓度为11 pg/ml或46%的妇女与可测量的雌二醇高。雌酮与雄烯二酮浓度呈正相关（r = 0.33，p < 0.001）。绝经后妇女的雌二醇浓度极低，因此，实验室误差的可能性更大。由于数据表明，雌酮水平可以更可靠地测量，事实上，与雌二醇水平，这是可能的雌酮水平可用于指示绝经后妇女的总雌激素状态。
Serum sex hormones may be related to the risk of several diseases in postmenopausal women including osteoporosis, heart disease, and breast and endometrial cancer. For assessment of the relation of sex hormones to disease, the measurements should be reliable, valid, and practical. In this paper, the authors evaluated the short-term (4-week) and long-term (2-year) reliability of serum sex hormones and interrelations among serum sex hormones in white postmenopausal women recruited in Pittsburgh, Pennsylvania, 1981-1986. For comparison, the authors simultaneously evaluated the short- and long-term reliability of other commonly measured risk factors, i.e., lipids, lipoproteins, and blood pressure. Serum concentrations of estrone, estradiol, testosterone, and androstenedione were measured by extraction, column chromatography, and radioimmunoassay. Reliability was estimated by calculating the intraclass correlation coefficients (R) and their 95% confidence interval. About 50% of the estradiol levels were below the sensitivity of the assay and, therefore, these results should be interpreted with some caution. The intraclass correlation coefficient for testosterone was 0.92 (95% confidence interval 1.0-082), suggesting that a single measure may be reliable in characterizing women for epidemiologic research. Over 4 weeks, estrone could be measured more reliably (R = 0.72) than over 2 years (R = 0.56), but the variability over the long term was similar to that observed for other biologic variables, suggesting that, in situations where the relation between estrone and disease is fairly substantial, a single measure may be used. For estradiol and androstenedione, the intraclass correlations were small, indicating poor reproducibility and the need for more measurements. Estrone concentrations were 11 pg/ml or 46% higher in women with measurable estradiol. Estrone was also positively related to androstenedione concentrations (r = 0.33, p < 0.001). Concentrations of estradiol are extremely low in postmenopausal women, and accordingly, there is a greater possibility of laboratory error. Since the data suggest that estrone levels can be more reliably measured and are, in fact, related to estradiol levels, it is possible that estrone levels may be used to indicate the total estrogen status of postmenopausal women.