Neural synchrony in schizophrenia: From networks to new treatments
Neural synchrony in schizophrenia: From networks to new treatments
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DOI：
10.1093/schbul/sbm062
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发表时间：
2007-07-01
影响因子：
6.6
通讯作者：
Mathalon, Daniel H.
中科院分区：
文献类型：
--
作者：
Ford, Judith M.;Krystal, John H.;Mathalon, Daniel H.
越来越多的证据表明，大脑区域在时间域中相互通信，依赖于神经活动的巧合来检测神经元和神经组件之间的相位关系。神经群体之间的这种协调被描述为“自组织”，这是神经网络的一种“涌现特性”，源于突触传递和不同神经元群体放电之间的时间同步。越来越多的证据表明，不同大脑区域之间的沟通和协调失败可能会导致精神分裂症的一系列问题，从精神病到认知功能障碍。我们回顾了有关精神分裂症神经振荡和振荡异常的功能神经解剖学和神经化学的知识。基于此，我们认为，我们可以开始使用振荡，跨频率，做翻译研究，以了解精神分裂症的神经基础。
Evidence is accumulating that brain regions communicate with each other in the temporal domain, relying on coincidence of neural activity to detect phasic relationships among neurons and neural assemblies. This coordination between neural populations has been described as "self-organizing," an "emergent property" of neural networks arising from the temporal synchrony between synaptic transmission and firing of distinct neuronal populations. Evidence is also accumulating that communication and coordination failures between different brain regions may account for a wide range of problems in schizophrenia, from psychosis to cognitive dysfunction. We review the knowledge about the functional neuroanatomy and neurochemistry of neural oscillations and oscillation abnormalities in schizophrenia. Based on this, we argue that we can begin to use oscillations, across frequencies, to do translational studies to understand the neural basis of schizophrenia.