Evidence for two conductance/exchange pathways for chloride in rat parotid secretory granules.
Evidence for two conductance/exchange pathways for chloride in rat parotid secretory granules.
复制标题
大鼠腮腺分泌颗粒中氯化物的两种电导/交换途径的证据。
DOI：
10.1016/s0006-291x(88)80593-x
复制
发表时间：
1988
影响因子：
3.1
通讯作者：
Wong,JL
中科院分区：
文献类型：
--
作者：
Goddard,MK;Izutsu,KT;Johnson,DE;EnsignJr,WY;Izutsu,SM;Wilkinson,LE;Chen,SW;Wong,JL
本文用电子探针X射线微区分析法测定了大鼠腮腺分泌颗粒在无菌Cl/Br洗脱实验早期的局部分布。氯离子流出和溴离子流入的分泌颗粒膜发生的时间顺序分钟。由于Cl洗脱数据表明颗粒内的Cl结合最小，因此Br结合最小，Br定位结果表明Cl（Br）离子在颗粒膜中存在两个或多个阴离子电导/交换途径。
Electron probe x-ray microanalysis was used to determine that bromide is localized to rat parotid secretory granules at early stages of aninsituCl/Br washout experiment. Chloride efflux and bromide influx across the secretory granule membrane occurred with a time order of minutes. Since the Cl washout data indicated minimal Cl binding within the granule, and therefore minimal Br binding, the Br localization results suggest the presence of two or more anion conductance/exchange pathways in the granule membrane for the Cl (Br) ion.