Chronic kidney disease and cognitive function in older adults: findings from the chronic renal insufficiency cohort cognitive study.
Chronic kidney disease and cognitive function in older adults: findings from the chronic renal insufficiency cohort cognitive study.
复制标题
DOI：
10.1111/j.1532-5415.2009.02670.x
复制
发表时间：
2010-02
影响因子：
6.3
通讯作者：
Chronic Renal Insufficiency Cohort Investigators
中科院分区：
文献类型：
--
作者：
Yaffe K;Ackerson L;Kurella Tamura M;Le Blanc P;Kusek JW;Sehgal AR;Cohen D;Anderson C;Appel L;Desalvo K;Ojo A;Seliger S;Robinson N;Makos G;Go AS;Chronic Renal Insufficiency Cohort Investigators
研究具有广泛肾功能的老年、种族多样性个体的认知功能障碍，评估认知领域谱，并确定CKD和认知功能之间的关系是否独立于人口统计学和临床因素。横截面。慢性肾功能不全队列研究。825例年龄≥55岁的CKD成人。我们使用四变量肾脏疾病饮食改良方程估计肾小球滤过率（eGFR，ml/min/1.73 m2）。我们使用线性回归比较了eGFR分层中六项认知测试的认知评分;使用多变量logistic回归检查CKD水平和临床显著认知障碍（评分与平均值相差≤1 sd）。参与者的平均年龄为64.9岁，50%为男性，45%为黑人。经多变量校正后，eGFR较低的受试者在大多数认知领域的认知得分较低（P<0.05）。此外，与轻度或中度CKD患者相比，（eGFR 45-59），晚期CKD受试者（eGFR <30）的患者更可能在整体认知方面有临床显著的认知障碍（校正比值比[OR] 2.0，95% CI 1.1-3.9），命名（OR 1.9，95% CI 1.0-3.3），注意（OR 2.4，95%CI 1.3-4.5）、执行功能（OR 2.5，95%CI 1.9- 4.4）和延迟记忆（OR=1.5，95%CI 0.9-2.6），但不影响类别流畅性（OR=1.1，95%CI 0.6-2.0）。在患有CKD的老年人中，肾功能水平较低与大多数领域的认知功能较低相关。我们的研究结果表明，老年晚期CKD患者应筛查认知功能障碍。
To investigate cognitive impairment in older, ethnically diverse individuals with a broad range of kidney function, to evaluate a spectrum of cognitive domains and to determine whether the relationship between CKD and cognitive function is independent of demographic and clinical factors. Cross sectional. Chronic Renal Insufficiency Cohort Study. 825 adults ≥55 years with CKD. We estimated glomerular filtration rate (eGFR, ml/min/1.73 m2) using the four-variable Modification of Diet in Renal Disease equation. We compared cognitive scores on six cognitive tests across eGFR strata using linear regression; multivariable logistic regression was used to examine level of CKD and clinically significant cognitive impairment (score ≤1 sd from mean). Mean age of the participants was 64.9 years, 50% were male and 45% were Black. After multi-variable adjustment, participants with lower eGFR had lower cognitive scores on most cognitive domains (P<0.05). In addition, compared with persons who had mild or moderate CKD (eGFR 45-59), participants with advanced CKD (eGFR <30) were more likely to have clinically significant cognitive impairment on global cognition (adjusted odds ratio [OR] 2.0, 95% CI 1.1-3.9), naming (OR 1.9, 95% CI 1.0-3.3), attention (OR 2.4, 95%CI 1.3-4.5), executive function (OR 2.5, 95%CI 1.9- 4.4) and delayed memory, (OR=1.5, 95%CI 0.9-2.6) but not on category fluency (OR=1.1, 95% CI 0.6-2.0). Among older adults with CKD, lower level of kidney function was associated with lower cognitive function on most domains. Our results suggest that older patients with advanced CKD should be screened for cognitive impairment.
登录
查看更多内容
DOI：
10.1097/01.asn.0000131529.60019.fa
发表时间：
2004-07-01
影响因子：
13.6
作者：
Seliger, SL;Siscovick, DS;Kuller, LH
通讯作者：
Kuller, LH
DOI：
10.1111/j.1532-5415.2004.52575.x
发表时间：
2004-12-01
影响因子：
6.3
作者：
Mehta, KM;Simonsick, EM;Yaffe, K
通讯作者：
Yaffe, K
影响因子：
6
作者：
Deng, A;Irizarry, MC;Rebeck, GW
通讯作者：
Rebeck, GW
影响因子：
5.7
作者：
Saxton, J;Ratcliff, G;Kuller, L
通讯作者：
Kuller, L
影响因子：
4.2
作者：
Sastre, M;Calero, M;Levy, E
通讯作者：
Levy, E