Chronic sleep disturbance and neural injury: links to neurodegenerative disease.
Chronic sleep disturbance and neural injury: links to neurodegenerative disease.
复制标题
慢性睡眠障碍和神经损伤：与神经退行性疾病的联系。
DOI：
10.2147/nss.s78947
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发表时间：
2016
影响因子：
3.4
通讯作者：
Videnovic A
中科院分区：
文献类型：
--
作者：
Abbott SM;Videnovic A
睡眠-觉醒中断是经常观察到的，并且通常是许多神经退行性疾病的最早报道的症状之一。这提供了对这些疾病的潜在病理生理学的深入了解，因为睡眠-觉醒异常通常伴有神经退行性或神经递质变化。然而，除了作为潜在神经退行性疾病的症状外，还有新的证据表明睡眠障碍本身可能有助于这些疾病的发展并促进其进展。由于其作为早期症状和促进持续神经退行性变的潜在因素的影响，睡眠-觉醒周期是进一步研究潜在干预措施的理想目标，不仅可以减轻这些疾病的负担，还可以减缓其进展。在这篇综述中，我们将突出与一些主要的神经退行性疾病相关的睡眠表型，重点关注与阿尔茨海默病相关的昼夜节律紊乱，与帕金森病相关的快速眼动行为障碍和睡眠片段化，以及与亨廷顿病相关的失眠和昼夜节律失调。
Sleep–wake disruption is frequently observed and often one of the earliest reported symptoms of many neurodegenerative disorders. This provides insight into the underlying pathophysiology of these disorders, as sleep–wake abnormalities are often accompanied by neurodegenerative or neurotransmitter changes. However, in addition to being a symptom of the underlying neurodegenerative condition, there is also emerging evidence that sleep disturbance itself may contribute to the development and facilitate the progression of several of these disorders. Due to its impact both as an early symptom and as a potential factor contributing to ongoing neurodegeneration, the sleep–wake cycle is an ideal target for further study for potential interventions not only to lessen the burden of these diseases but also to slow their progression. In this review, we will highlight the sleep phenotypes associated with some of the major neurodegenerative disorders, focusing on the circadian disruption associated with Alzheimer’s disease, the rapid eye movement behavior disorder and sleep fragmentation associated with Parkinson’s disease, and the insomnia and circadian dysregulation associated with Huntington’s disease.