The effect of bone morphometric changes on orthodontic tooth movement in an osteoporotic animal model
The effect of bone morphometric changes on orthodontic tooth movement in an osteoporotic animal model
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DOI：
10.2319/111312-869.1
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发表时间：
2013-09-01
影响因子：
3.4
通讯作者：
Yoshida, Noriaki
中科院分区：
文献类型：
--
作者：
Hashimoto, Megumi;Hotokezaka, Hitoshi;Yoshida, Noriaki
目的：探讨唑来膦酸对去卵巢大鼠正畸牙移动(OTM)的影响。材料与方法：21只10周龄雌性Wistar大鼠随机分为去卵巢组(OVX)、去卵巢+ZOL组(OVX+ZOL)和假手术组(对照组)。OVX两周后开始ZOL给药。去势12周后，向上颌左第一磨牙近中方向施加25g力的镍钛闭合弹簧。去势后每隔2周行左侧胫骨近端CT骨形态计量学分析。结果：骨小梁的骨矿含量(BMC)、骨体积(BV)、骨矿/组织体积比(BMC/TV)、骨/组织体积比(BMC/TV)在对照组与OVX组、OVX+ZOL组与OVX组之间均有显著差异。OVX+ZOL组皮质骨BMC、BV增加，松质骨骨密度(BMD)增加。有趣的是，OVX组的OTM几乎是对照组和OVX+ZOL组的两倍。OTM与骨小梁的BMD、BMC、BV、BMC/TV呈正相关。结论：OVX促进OTM，ZOL抑制OTM。OTM与骨小梁质量呈显著负相关。
Objective: To elucidate the effect of bone morphometric changes on orthodontic tooth movement (OTM) in zoledronic acid treated ovariectomized rats.Materials and Methods: Twenty-one 10-week-old female Wistar rats were divided into ovariectomy (OVX), OVX with zoledronic acid administration (OVX + ZOL), and sham operation (control) groups. Two weeks after OVX, ZOL administration was initiated. Twelve weeks after OVX, a nickel-titanium closed-coil spring of 25-g force was applied mesially to the maxillary left first molar. In vivo micro-computed tomography (CT) of the left proximal tibia was performed for bone morphometric analysis every 2 weeks after OVX. In addition, OTM was investigated using micro-CT at 0, 12, and 14 weeks after OVX.Results: There were significant differences in the bone mineral content (BMC), bone volume (BV), BMC to tissue volume ratio (BMC/TV), and BV to TV ratio of trabecular bone between the control and OVX groups and also between the OVX + ZOL and OVX groups. In the OVX + ZOL group, increased BMC and BV in the cortical bone and increased bone mineral density (BMD) in the trabecular bone were observed. Interestingly, OTM in the OVX group was almost two times more than that in the control and OVX + ZOL groups. Moreover, OTM was correlated with BMD, BMC, BV, and BMC/TV in the trabecular bone.Conclusions: OVX accelerated OTM, while ZOL suppressed it. OTM demonstrated a significant negative relationship with trabecular bone mass.