Role of autophagy in the pathophysiology of nonalcoholic fatty liver disease: A controversial issue
Role of autophagy in the pathophysiology of nonalcoholic fatty liver disease: A controversial issue
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DOI：
10.3748/wjg.v20.i23.7325
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发表时间：
2014-06-21
影响因子：
4.3
通讯作者：
Francque, Sven M.
中科院分区：
文献类型：
--
作者：
Kwanten, Wilhelmus J.;Martinet, Wim;Francque, Sven M.
自噬是在基础和应激条件下参与细胞内稳态的机制，其将细胞质内容物递送至溶酶体以降解为大量营养素。在过去的十年中，自噬在疾病中的潜在作用越来越多地被认识和研究。目前普遍认为自噬在肝脏脂质代谢中起一定作用。因此，自噬功能障碍可能是非酒精性脂肪肝的潜在原因。然而，自噬在脂质代谢中的确切作用存在争议：一些出版物报道了自噬的脂解功能，而另一些则声称具有脂肪生成功能。本文就自噬在肝脏脂质代谢、肝脏胰岛素抵抗、脂肪性肝炎及肝纤维化中的作用作一综述。(C)2014百世登出版集团股份有限公司All rights reserved.
Autophagy is a mechanism involved in cellular homeostasis under basal and stressed conditions delivering cytoplasmic content to the lysosomes for degradation to macronutrients. The potential role of autophagy in disease is increasingly recognised and investigated in the last decade. Nowadays it is commonly accepted that autophagy plays a role in the hepatic lipid metabolism. Hence, dysfunction of autophagy may be an underlying cause of non-alcoholic fatty liver disease. However, controversy of the exact role of autophagy in the lipid metabolism exists: some publications report a lipolytic function of autophagy, whereas others claim a lipogenic function. This review aims to give an update of the present knowledge on autophagy in the hepatic lipid metabolism, hepatic insulin resistance, steatohepatitis and hepatic fibrogenesis. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.