Vascular changes in neuroblastoma of mice following x-irradiation.
Vascular changes in neuroblastoma of mice following x-irradiation.
复制标题
X 射线照射后小鼠神经母细胞瘤的血管变化。
作者：
C. Song;J. H. Sung;J. Clement;S. Levitt
研究了x射线照射后a /J小鼠可移植神经母细胞瘤血管的变化。单次照射剂量低于500拉德的x射线照射，在照射1天后用51cr标记的红细胞测量，导致功能性血管内体积略有增加，此后逐渐减少。相比之下，1000和2000拉德的x射线照射诱导血管体积在照射后1天减小，此后逐渐减小。血浆蛋白外渗，用125i标记血浆蛋白测定，在250 ~ 2000拉德辐照后很快增加，然后减少。肿瘤的组织病理学研究显示，随着肿瘤细胞数量减少或肿瘤小叶消退，血管床逐渐拥挤或凝结。直接辐照引起的血管损伤和辐照后血管网络结构的紊乱似乎会导致血管闭塞并干扰肿瘤内的血液流动。
Vascular changes in a transplantable neuroblastoma of A/J mice following X-irradiation were studied. X-irradiation with doses lower than 500 rads in a single exposure caused a slight increase in the functional intravascular volume, as measured with 51Cr-labeled red cells 1 day after the irradiation, and a gradual decrease thereafter. X-irradiation with 1000 and 2000 rads, in contrast, induced a decrease in the vascular volume at 1 day postirradiation and a further gradual decrease thereafter. The extravasation of plasma protein, as measured with 125I-labeled plasma protein, increased soon after irradiation with doses of 250 to 2000 rads, and then decreased. Histopathological studies of tumors irradiated with 2000 rads revealed a progressive crowding or condensation of the vascular bed as the tumor cell population became reduced or tumor lobules receded. Direct irradiation-induced damage to the vessels and the disorganization of the architecture of vascular networks following irradiation appear to cause vascular occlusion and interfere with the blood flow in the tumors.