Evaluation of relationship between common carotid artery intima-media thickness and coronary in-stent restenosis: A case-control study.
Evaluation of relationship between common carotid artery intima-media thickness and coronary in-stent restenosis: A case-control study.
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DOI：
10.1556/1646.10.2018.08
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发表时间：
2018-03
影响因子：
--
通讯作者：
Srinivas R
中科院分区：
文献类型：
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作者：
Bhavanadhar P;Reddy YVS;Otikunta AN;Srinivas R
本研究旨在评估颈总动脉内膜-中膜厚度（CIMT）与冠状动脉支架内再狭窄（ISR）的关系，并评估患者的临床特征，以确定冠状动脉支架内再狭窄的预测因素。这是一项2012年12月至2015年2月在印度进行的单中心病例对照研究。研究人群包括pci治疗的ISR患者（n = 32）和在研究期前至少6个月没有任何pci后症状的患者（n = 40）。定量冠脉造影测定ISR。病例组和对照组的平均CIMT分别为0.96±0.23和0.66±0.09 mm （OR = 57, p < 0.001）。25%的病例和95%的对照组的CIMT <0.8 mm。在多因素分析中，高血压的存在（OR = 10.79, p = 0.026）和较大的支架直径（OR = 14.87, p = 0.039）与ISR的存在增加独立相关。CIMT <0.8 mm （OR = 0.03, p = 0.025）、STEMI （OR = 0.03, p = 0.004）和估计肾小球滤过率bbb50 ml/min （OR = 0.005, p = 0.014）与较低的ISR存在独立相关。CIMT升高似乎是ISR升高的独立风险指标。由于CIMT是非侵入性参数，在常规临床实践中，pci后随访测量CIMT将为预测再狭窄率提供潜在的好处。
The study was intended to evaluate relationship of common carotid artery intima-media thickness (CIMT) with coronary in-stent restenosis (ISR) and to assess clinical profile of patients to determine the predictors of coronary ISR. This was a single-center, case-control study performed between December 2012 and February 2015 in India. The study population consisted of PCI-treated patients with ISR (n = 32) and those without any post-PCI symptoms at least 6 months prior to the study period (n = 40). Quantitative coronary angiography was performed in patients to determine ISR. Average CIMT for cases and controls was 0.96 ± 0.23 and 0.66 ± 0.09 mm (OR = 57, p < 0.001), respectively. CIMT was <0.8 mm in 25% of cases and 95% of controls. On multivariate analysis, presence of hypertension (OR = 10.79, p = 0.026) and higher stent diameter (OR = 14.87, p = 0.039) were independently associated with increased presence of ISR. CIMT <0.8 mm (OR = 0.03, p = 0.025), STEMI (OR = 0.03, p = 0.004), and estimated glomerular filtration rate >50 ml/min (OR = 0.005, p = 0.014) were independently associated with lower presence of ISR. Elevated CIMT appears to be an independent risk indicator for increased ISR. As CIMT is a non-invasive parameter, post-PCI follow-up measurements of CIMT in routine clinical practice will provide potential benefits to predict the restenosis rates.