Serotonin uptake in blood platelets of psychiatric patients.
Serotonin uptake in blood platelets of psychiatric patients.
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DOI：
10.1001/archpsyc.1981.01780370024002
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发表时间：
1981-12
影响因子：
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通讯作者：
H. Meltzer;Ramesh Chandra Arora;R. Baber;B. J. Tricou
中科院分区：
文献类型：
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作者：
H. Meltzer;Ramesh Chandra Arora;R. Baber;B. J. Tricou
测定了72例新入院的未经药物治疗的精神病患者的血小板5-羟色胺（5-HT）摄取。单相抑郁症、双相抑郁症和双情感性抑郁症患者5-HT摄取最大速度（Vmax）均降低。5-HT摄取的表观米氏常数（km）在这些组中是正常的，躁狂抑郁症和慢性精神分裂症患者的Vmax和Km也是正常的。用盐酸诺替林或盐酸丙咪嗪治疗抑郁症患者可使Km显著增加。去甲替林治疗患者的Km增加有与临床改善相关的趋势。血小板中5-HT摄取减少为5-HT在某些形式的抑郁症的病理生理过程中的作用提供了额外的证据。
Platelet serotonin (5-HT) uptake was determined in 72 newly admitted, unmedicated psychiatric patients. Decreased maximum velocity (Vmax) of 5-HT uptake was present in unipolar and bipolar depressed patients as well as schizoaffective depressed patients. The apparent Michaelis constant (km) of 5-HT uptake was normal in these groups, as was Vmax and Km in manic-depressive and chronic schizophrenic patients. Treatment of depressed patients with notriptyline hydrochloride or imipramine hydrochloride increased Km significantly. There was a trend for the increase in Km in the nortriptyline-treated patients to correlate with clinical improvement. Decreased 5-HT uptake in platelets provides additional evidence for the role of 5-HT in the pathophysiologic process of some forms of depression.