LACTATE TRANSPORT THROUGH THE BLOOD-RETINAL AND THE BLOOD-BRAIN-BARRIER IN RATS
LACTATE TRANSPORT THROUGH THE BLOOD-RETINAL AND THE BLOOD-BRAIN-BARRIER IN RATS
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DOI：
10.1159/000265371
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发表时间：
1985-01-01
影响因子：
2.1
通讯作者：
TORNQUIST, P
中科院分区：
文献类型：
--
作者：
ALM, A;TORNQUIST, P
在大鼠研究中采用视网膜和大脑摄取指数方法来分别评估血视网膜和血脑屏障中乳酸转运系统的存在。对于视网膜和大脑，观察到 L-乳酸的饱和、pH 依赖性吸收。丙酮酸和3-羟基丁酸也可以抑制摄取。乳酸盐可以通过类似的载体介导的转运系统转运通过血视网膜和血脑屏障，该转运系统也对其他一元羧酸（例如丙酮酸）和酮体3-羟基丁酸酯具有亲和力。乳酸转运的 pH 依赖性表明发生了 H+ 离子的共转运或 OH- 离子的反向转运。
The retinal and brain uptake index method was utilized in a study on rats to evaluate the existence of transport systems for lactate in the blood-retinal and the blood-brain barrier, respectively. For both retina and brain a saturable, pH-dependent uptake of L-lactate was observed. The uptake could also be inhibited by pyruvate and 3-hydroxybutyrate. Lactate maybe transported through the blood-retinal and the blood-brain barriers by similar carrier-mediated transport systems with affinity also to other monocarboxylic acids, such as pyruvate, and to the ketone body 3-hydroxybutyrate. The pH-dependence of the lactate transport suggests that cotransport of H+ ions or counter-transport of OH- ions take place.