Probing tumor microvascularity by measurement, analysis and display of contrast agent uptake kinetics
Probing tumor microvascularity by measurement, analysis and display of contrast agent uptake kinetics
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DOI：
10.1002/jmri.1880070318
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发表时间：
1997-05-01
期刊：
影响因子：
--
通讯作者：
Leach, MO
中科院分区：
文献类型：
--
作者：
Parker, GJM;Suckling, J;Leach, MO
本文描述了一种用于获取定量动态MRI数据的测量协议和新的分析和显示软件(MRIW)。使用质子密度加权和T1加权二维梯度回波图像来定量组织造影剂浓度。动态研究持续约7分钟，时间分辨率为10秒。分析信号和浓度随时间的变化，使毛细血管渗透率-表面积乘积、组织渗漏空间、增强开始时间、平均增强梯度和最大增强水平被映射为与解剖图像配准的假彩色参数覆盖。渗透性和渗漏空间的量化提供了一种在不同就诊之间比较患者生理或进行站点间比较的方法。
This paper describes a measurement protocol for acquiring quantitative dynamic MRI data and novel analysis and display software (Magnetic Resonance Imaging Workbench (MRIW)). Proton density-weighted and T1-weighted two-dimensional gradient echo images are used to quantify tissue contrast agent concentration. The dynamic studies last approximately 7 minutes, with 10-second temporal resolution. Analyses of signal and concentration changes with time are performed, allowing capillary permeability-surface area product, tissue leakage space, enhancement onset time, mean enhancement gradient and maximum enhancement level to be mapped as false-color parametric overlays registered with anatomic images. Quantification of permeability and leakage space provides a method for comparing physiology in patients between visits or for intersite comparisons.