Reply: taste loss as a distinct symptom of COVID-19: a systematic review and meta-analysis.
Reply: taste loss as a distinct symptom of COVID-19: a systematic review and meta-analysis.
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答复：味觉丧失作为 COVID-19 的一个独特症状：系统评价和荟萃分析。
DOI：
10.1093/chemse/bjad012
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发表时间：
2023
期刊：
影响因子：
3.5
通讯作者：
Reed,DanielleR
中科院分区：
文献类型：
--
作者：
Hannum,MackenzieE;Koch,RileyJ;Ramirez,VicenteA;Marks,SarahS;Toskala,AuroraK;Herriman,RileyD;Lin,Cailu;Joseph,PauleV;Reed,DanielleR
化学感应科学家一直怀疑有关 COVID-19 味觉丧失的报道的真实性，部分原因是在 COVID-19 之前，味觉丧失很少见，而且经常与嗅觉丧失相混淆。因此，为了确定 COVID-19 患者味觉丧失的预测患病率，我们对 2020-2021 年发表的 376 篇论文进行了系统回顾和荟萃分析，其中 235 篇论文符合所有纳入标准。借鉴以前的研究并在早期荟萃分析的指导下，我们探讨了方法差异（直接与自我报告测量）如何影响这些估计。我们假设直接测量味觉至少与通过自我报告获得的测量一样敏感，并且大量证据证实味觉丧失是 COVID-19 的症状。荟萃分析显示，在 138,015 名 COVID-19 阳性患者中，36.62% 报告味觉功能障碍（95% 置信区间：33.02%–40.39%），使用直接（n= 15）与自我报告（n= 220）方法的研究相比，患病率估计值略高，但不显着较高（Q = 1.73，df = 1，P = 0.1889）。一般来说，男性的味觉丧失率低于女性，其中中年人的味觉丧失率最高。因此，味觉丧失可能是 COVID-19 的真正症状，值得进一步研究最合适的直接测量方法及其潜在机制。
Chemosensory scientists have been skeptical that reports of COVID-19 taste loss are genuine, in part because before COVID-19 taste loss was rare and often confused with smell loss. Therefore, to establish the predicted prevalence rate of taste loss in COVID-19 patients, we conducted a systematic review and meta-analysis of 376 papers published in 2020–2021, with 235 meeting all inclusion criteria. Drawing on previous studies and guided by early meta-analyses, we explored how methodological differences (direct vs. self-report measures) may affect these estimates. We hypothesized that direct measures of taste are at least as sensitive as those obtained by self-report and that the preponderance of evidence confirms taste loss is a symptom of COVID-19. The meta-analysis showed that, among 138,015 COVID-19-positive patients, 36.62% reported taste dysfunction (95% confidence interval: 33.02%–40.39%), and the prevalence estimates were slightly but not significantly higher from studies using direct (n= 15) versus self-report (n= 220) methodologies (Q= 1.73, df = 1,P= 0.1889). Generally, males reported lower rates of taste loss than did females, and taste loss was highest among middle-aged adults. Thus, taste loss is likely a bona fide symptom of COVID-19, meriting further research into the most appropriate direct methods to measure it and its underlying mechanisms.