A TRIPLE DISSOCIATION OF MEMORY-SYSTEMS - HIPPOCAMPUS, AMYGDALA, AND DORSAL STRIATUM
A TRIPLE DISSOCIATION OF MEMORY-SYSTEMS - HIPPOCAMPUS, AMYGDALA, AND DORSAL STRIATUM
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DOI：
10.1037/0735-7044.107.1.3
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发表时间：
1993-02-01
影响因子：
1.9
通讯作者：
WHITE, NM
中科院分区：
文献类型：
--
作者：
MCDONALD, RJ;WHITE, NM
这项研究调查了海马体、杏仁体和背侧纹状体在学习和记忆中各自的作用。使用8臂放射状迷宫研究损伤对三个脑区的影响的一组标准实验条件：Win-Shift版本、条件线索偏好(CCP)版本和Win-Stay版本。海马体系统的损伤损害了Win-Shift任务的获得，但不影响CCP或Win-Stay任务的获得。杏仁外侧核的损伤损害了CCP任务的习得，但不影响Win-Shift或Win-Stay任务。损毁背侧纹状体损害了Win-Stay任务的获得，但不影响Win-Shift或CCP任务的获得。这些结果与哺乳动物大脑可能能够通过不同的或多或少独立的神经系统获取不同类型信息的假设一致。包括海马体的神经系统可以获取有关刺激和事件之间关系的信息。包括杏仁核在内的神经系统可能会调节基于具有情感属性的生物重大事件的行为的快速获得。包括背侧纹状体的神经系统可能参与加强刺激-反应联系的形成。
This study investigated the respective roles of the hippocampus, the amygdala, and the dorsal striatum in learning and memory. A standard set of experimental conditions for studying the effects of lesions to the three brain areas using an 8-arm radial maze was used: a win-shift version, a conditioned cue preference (CCP) version, and a win-stay version. Damage to the hippocampal system impaired acquisition of the win-shift task but not the CCP or win-stay tasks. Damage to the lateral amygdala impaired acquisition of the CCP task but not the win-shift or win-stay tasks. Damage to the dorsal striatum impaired acquisition of the win-stay task but not the win-shift or CCP tasks. These results are consistent with the hypothesis that the mammalian brain may be capable of acquiring different kinds of information with different, more-or-less independent neural systems. A neural system that includes the hippocampus may acquire information about the relationships among stimuli and events. A neural system that includes the amygdala may mediate the rapid acquisition of behaviors based on biologically significant events with affective properties. A neural system that includes the dorsal striatum may mediate the formation of reinforced stimulus-response associations.