ATHEROSCLEROSIS IN TRANSGENIC MICE OVEREXPRESSING APOLIPOPROTEIN-A-II
ATHEROSCLEROSIS IN TRANSGENIC MICE OVEREXPRESSING APOLIPOPROTEIN-A-II
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DOI：
10.1126/science.8332912
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发表时间：
1993-07-23
期刊：
影响因子：
56.9
通讯作者：
LUSIS, AJ
中科院分区：
文献类型：
--
作者：
WARDEN, CH;HEDRICK, CC;LUSIS, AJ
血浆高密度脂蛋白（HDL）浓度与动脉粥样硬化性冠状动脉疾病呈负相关。HDL的两种最丰富的蛋白质成分是载脂蛋白A-I和A-II（apoA-I和apoA-II）。ApoA-I是HDL组装所必需的，当在转基因小鼠中过表达时，赋予对早期动脉粥样硬化的抵抗力。目前的研究表明，过表达小鼠apoA-II的转基因小鼠具有升高的HDL-胆固醇浓度，但与正常小鼠相比，表现出增加的动脉粥样硬化病变的发展。转基因小鼠的HDL更大，apoA-II与apoA-I的比例增加。因此，高密度脂蛋白的组成和含量似乎是动脉粥样硬化的重要决定因素。
Concentrations of plasma high density lipoprotein (HDL) are inversely correlated with atherosclerotic coronary artery disease. The two most abundant protein constituents of HDL are apolipoproteins A-I and A-II (apoA-I and apoA-II). ApoA-I is required for assembly of HDL and, when overexpressed in transgenic mice, confers resistance to early atherosclerosis. The present studies reveal that transgenic mice that overexpress mouse apoA-II had elevated HDL-cholesterol concentrations but, nevertheless, exhibited increased atherosclerotic lesion development as compared to normal mice. The HDL in the transgenic mice was larger and had an increased ratio of apoA-II to apoA-I. Thus, both the composition and amount of HDL appear to be important determinants of atherosclerosis.