Overlapping representations for grip type and reach direction
Overlapping representations for grip type and reach direction
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DOI：
10.1016/j.neuroimage.2014.03.017
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发表时间：
2014-07-01
期刊：
影响因子：
5.7
通讯作者：
Lingnau, Angelika
中科院分区：
文献类型：
--
作者：
Fabbri, Sara;Strnad, Lukas;Lingnau, Angelika
为了抓住一个物体，我们需要向它移动手臂，并采取适当的手部配置。虽然以前的研究表明，大脑的背内侧和背外侧通路分别专门负责运输和抓握成分，但最近的研究对这种明确的区分提出了质疑。然而，目前尚不清楚神经元群体对这两种成分的选择在多大程度上重叠，如果重叠，又在多大程度上相互作用。在这里，我们使用功能磁共振成像（fMRI）数据的多体素模式分析（MVPA）来研究在五个到达方向上进行的三种中心向外运动（触摸，钳握，全手握）的表征。我们发现，到达方向的选择性只存在于后和吻侧上顶叶（SPLp, SPLr）、辅助运动区（SMA）和背侧运动前皮层（PMDs）的上部分。相反，我们发现在背侧运动前皮层（PMDi）、腹侧运动前皮层（PMv）、顶叶前沟（aIPS）、初级运动（M1）、体感（S1）皮层和顶叶前上叶（SPLa）的下部分，对握力类型和到达方向都有选择性。在这些区域内，PMv、M1、aIPS和SPLa在输运组分和握持组分之间表现出弱相互作用。我们的研究结果表明，人类PMDi和Si都含有握力和到达方向选择性神经元群，这些神经元群保持了它们的功能独立性，而这些信息可能在PMv、M1、aIPS和SPLa水平上结合在一起。(C) 2014爱思唯尔公司版权所有。
To grasp an object, we need to move the arm toward it and assume the appropriate hand configuration. While previous studies suggested dorsomedial and dorsolateral pathways in the brain specialized respectively for the transport and grip components, more recent studies cast doubt on such a clear-cut distinction. It is unclear, however, to which degree neuronal populations selective for the two components overlap, and if so, to which degree they interact. Here, we used multivoxel pattern analysis (MVPA) of functional magnetic resonance imaging (fMRI) data to investigate the representation of three center-out movements (touch, pincer grip, whole-hand grip) performed in five reach directions. We found selectivity exclusively for reach direction in posterior and rostral superior parietal lobes (SPLp, SPLr), supplementary motor area (SMA), and the superior portion of dorsal premotor cortex (PMDs). Instead, we found selectivity for both grip type and reach direction in the inferior portion of dorsal premotor cortex (PMDi), ventral premotor cortex (PMv), anterior intraparietal sulcus (aIPS), primary motor (M1), somatosensory (S1) cortices and the anterior superior parietal lobe (SPLa). Within these regions, PMv, M1, aIPS and SPLa showed weak interaction g between the transport and grip components. Our results suggest that human PMDi and Si contain both grip- and reach-direction selective neuronal populations that retain their functional independence, whereas this information might be combined at the level of PMv, M1, aIPS, and SPLa. (C) 2014 Elsevier Inc. All rights reserved.