Angiogenesis in normal and neoplastic ovaries
Angiogenesis in normal and neoplastic ovaries
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DOI：
10.1007/s10456-005-9001-1
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发表时间：
2005-01-01
期刊：
影响因子：
9.8
通讯作者：
Geller, M.
中科院分区：
文献类型：
--
作者：
Ramakrishnan, S.;Subramanian, I. V.;Geller, M.
卵巢生理学与卵巢调节的血管生成反应密切相关。后基因组革命的最新进展显著影响了我们对卵巢功能的理解。从血管生成的角度来看，卵巢提供了一个独特的机会来解开正常条件下血管发育和退化的分子编排。大多数卵巢癌从卵巢周围的单层上皮发展而来。血管生成在卵巢癌的发展及其腹膜转移中起着关键作用。本文综述了近年来卵巢肿瘤血管生成反应的研究进展，并讨论了抗血管生成治疗卵巢癌的前景。
Ovarian physiology is intricately connected to hormonally regulated angiogenic response. Recent advances in the post genomic revolution have significantly impacted our understanding of ovarian function. In an angiogenesis perspective, the ovary offers a unique opportunity to unravel the molecular orchestration of blood vessel development and regression under normal conditions. A majority of ovarian cancers develop from the single layer of epithelium surrounding the ovaries. Angiogenesis is critical for the development of ovarian cancer and its peritoneal dissemination. The present review summarizes recent findings on the angiogenic response in neoplastic ovaries and discusses the prospects of using anti-angiogenic approaches to treat ovarian cancer.