The role of novel cytokines in inflammation: Defining peripheral artery disease among patients with coronary artery disease
The role of novel cytokines in inflammation: Defining peripheral artery disease among patients with coronary artery disease
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DOI：
10.1177/1358863x18763096
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发表时间：
2018-10-01
影响因子：
3.5
通讯作者：
Guler, Niyazi
中科院分区：
文献类型：
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作者：
Gur, Demet Ozkaramanli;Guzel, Savas;Guler, Niyazi
与仅患有 CAD 的患者相比，伴有外周动脉疾病 (PAD) 的冠状动脉疾病 (CAD) 患者会经历更广泛和钙化的动脉粥样硬化、更大的病变进展和更常见的冠状动脉事件。为了表征这种侵袭性动脉粥样硬化疾病的独特特征，我们研究了编码动脉粥样硬化不同阶段的新型细胞因子。在计划进行冠状动脉造影的稳定型心绞痛患者中招募了 180 名连续受试者（CAD+PAD、CAD 和对照各组 60 名患者）。踝臂指数 (ABI) 0.9 被确定为闭塞性 PAD。测定空腹血清肿瘤坏死因子（TNF）样抗原1A（TL1A）及其受体死亡受体3（DR3）、NOGO-B（reticulon 4B）及其受体NUS1、高敏C反应蛋白（hsCRP）、具有血小板反应蛋白基序的解整合素和金属蛋白酶（ADAMTS）1、4、5和白细胞介素（IL）6的水平。 CAD 组和 CAD+PAD 组的血清 hsCRP 和 DR3/TL1A 浓度相似且高于对照组。 CAD+PAD 患者中 NOGO-B 及其受体 NUS1 水平升高，ADAMTS-5 水平降低。多变量分析中 ABI 的独立预测因子是吸烟 (B = -0.13，p = 0.04)、NUS1 (B = -0.88，p < 0.001)、ADAMTS-5 (B = 0.63，p < 0.001) 和 SYNTAX 评分 (B = -0.26，p < 0.001)。同样，吸烟 (OR = 5.5，p = 0.019)、SYNTAX 评分 (OR = 1.2，p < 0.001)、NUS1 (OR = 14.4，p < 0.001)、ADAMTS-5 (OR = 1.1，p < 0.001) 和年龄 (OR = 1.1，p = 0.042) 独立预测外周血管系统的受累在逻辑回归中。这些细胞因子区分 CAD+PAD 的诊断性能对于 NUS1 为 0.79 (p < 0.001)，对于 ADAMTS-5 为 0.37 (p = 0.013)。我们在此报告，循环细胞因子可以为正在进行的动脉粥样硬化过程和血管受累程度提供线索，其中 ADAMTS-5 和 NUS1 的独特特征使它们成为未来研究有希望的细胞因子。
Coronary artery disease (CAD) patients with concomitant peripheral artery disease (PAD) experience more extensive and calcified atherosclerosis, greater lesion progression and more common coronary events compared to patients with CAD only. To characterize the distinct features of this aggressive atherosclerotic disease, we studied novel cytokines that code different stages of atherogenesis. One hundred and eighty consecutive subjects (60 patients into each group of CAD+PAD, CAD and controls) were recruited among patients with stable angina pectoris scheduled for coronary angiography. An ankle-brachial index (ABI) 0.9 was determined as occlusive PAD. Fasting serum tumor necrosis factor (TNF)-like antigen 1A (TL1A) and its receptor death receptor 3 (DR3), NOGO-B (reticulon 4B) and its receptor NUS1, high-sensitivity C-reactive protein (hsCRP), A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) 1, 4, 5 and interleukin (IL) 6 levels were determined. Serum hsCRP and DR3/TL1A concentrations were similar and higher than controls in the CAD and CAD+PAD groups. Levels of NOGO-B and its receptor NUS1 were increased and ADAMTS-5 was decreased in patients with CAD+PAD. Independent predictors of ABI in multivariate analysis were smoking (B = -0.13, p = 0.04), NUS1 (B = -0.88, p < 0.001), ADAMTS-5 (B = 0.63, p < 0.001) and SYNTAX score (B = -0.26, p < 0.001). Similarly, smoking (OR = 5.5, p = 0.019), SYNTAX score (OR = 1.2, p < 0.001), NUS1 (OR = 14.4, p < 0.001), ADAMTS-5 (OR = 1.1, p < 0.001) and age (OR = 1.1, p = 0.042) independently predicted the involvement of peripheral vasculature in logistic regression. The diagnostic performance of these cytokines to discriminate CAD+PAD were AUC 0.79 (p < 0.001) for NUS1 and 0.37 (p = 0.013) for ADAMTS-5. We report herein that circulating cytokines can give clues to the ongoing atherosclerotic process and the extent of vascular involvement in which distinct features of ADAMTS-5 and NUS1 make them promising cytokines for future research.