Ozone exposure, vitamin C intake, and genetic susceptibility of asthmatic children in Mexico City: a cohort study.
Ozone exposure, vitamin C intake, and genetic susceptibility of asthmatic children in Mexico City: a cohort study.
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DOI：
10.1186/1465-9921-14-14
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发表时间：
2013-02-04
影响因子：
5.8
通讯作者：
Romieu I
中科院分区：
文献类型：
--
作者：
Moreno-Macías H;Dockery DW;Schwartz J;Gold DR;Laird NM;Sienra-Monge JJ;Del Río-Navarro BE;Ramírez-Aguilar M;Barraza-Villarreal A;Li H;London SJ;Romieu I
我们以前报道过GSTM 1缺失基因型的哮喘儿童可能更容易受到臭氧对小气道的急性影响，并可能受益于抗氧化剂的补充。本研究旨在评估臭氧对哮喘儿童肺功能（FEF 25 -75）的急性影响，根据膳食中维生素C的摄入量和三种抗氧化基因中假定的风险等位基因的数量：GSTM 1，GSTP 1（rs 1695）和NQO 1（rs 1800566）。在墨西哥城进行的两项队列研究中，纳入了257名哮喘儿童。分层线性混合模型与随机截距和随机斜率的臭氧。评估了种族的潜在混杂因素。根据单基因和基因型评分方法进行分析。在维生素C摄入量低且GSTM 1无效的持续性哮喘儿童中，FEF 25 -75每四分位数范围（60 ppb）臭氧的变化为−91.2 ml/s（p = 0.06）。具有4 - 6个风险等位基因和低维生素C摄入量的持续性哮喘儿童显示FEF 25 -75平均下降97.2 ml/s/60 ppb臭氧（p = 0.03）。相反，在1至3个风险等位基因的儿童中，臭氧对FEF 25 -75的急性影响并没有因维生素C摄入量而异。我们的研究结果提供了进一步的证据，哮喘儿童预测有妥协的抗氧化防御凭借遗传易感性结合缺乏抗氧化剂的摄入量可能会增加臭氧对肺功能的不良影响的风险。
We previously reported that asthmatic children with GSTM1 null genotype may be more susceptible to the acute effect of ozone on the small airways and might benefit from antioxidant supplementation. This study aims to assess the acute effect of ozone on lung function (FEF25-75) in asthmatic children according to dietary intake of vitamin C and the number of putative risk alleles in three antioxidant genes: GSTM1, GSTP1 (rs1695), and NQO1 (rs1800566). 257 asthmatic children from two cohort studies conducted in Mexico City were included. Stratified linear mixed models with random intercepts and random slopes on ozone were used. Potential confounding by ethnicity was assessed. Analyses were conducted under single gene and genotype score approaches. The change in FEF25-75 per interquartile range (60 ppb) of ozone in persistent asthmatic children with low vitamin C intake and GSTM1 null was −91.2 ml/s (p = 0.06). Persistent asthmatic children with 4 to 6 risk alleles and low vitamin C intake showed an average decrement in FEF25-75 of 97.2 ml/s per 60 ppb of ozone (p = 0.03). In contrast in children with 1 to 3 risk alleles, acute effects of ozone on FEF25-75 did not differ by vitamin C intake. Our results provide further evidence that asthmatic children predicted to have compromised antioxidant defense by virtue of genetic susceptibility combined with deficient antioxidant intake may be at increased risk of adverse effects of ozone on pulmonary function.
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DOI：
10.1164/rccm.200305-684oc
发表时间：
2003-11-15
影响因子：
24.7
作者：
David, GL;Romieu, I;London, SJ
通讯作者：
London, SJ
影响因子：
5.6
作者：
Lam, Tram Kim;Ruczinski, Ingo;Alberg, Anthony J.
通讯作者：
Alberg, Anthony J.
DOI：
10.1590/s0036-36342008000100013
发表时间：
2008-02-01
期刊：
Salud Pública de México
影响因子：
--
作者：
Ramírez-Aguilar, Matiana;Barraza-Villarreal, Albino;Romieu, Isabelle
通讯作者：
Romieu, Isabelle
影响因子：
5.8
作者：
Kim JH;Ellwood PE;Asher MI
通讯作者：
Asher MI
影响因子：
10.6
作者：
Mudway, I. S.;Kelly, F. J.
通讯作者：
Kelly, F. J.