Successful Treatment of Influenza-Associated Acute Necrotizing Encephalitis in an Adult Using High-Dose Oseltamivir and Methylprednisolone: Case Report and Literature Review.
Successful Treatment of Influenza-Associated Acute Necrotizing Encephalitis in an Adult Using High-Dose Oseltamivir and Methylprednisolone: Case Report and Literature Review.
复制标题
使用高剂量的oseltamivir和甲基甲溶质龙的成年人成功治疗了与流感相关的急性坏死性脑炎：病例报告和文献综述。
DOI：
10.1093/ofid/ofx145
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发表时间：
2017
影响因子：
4.2
通讯作者：
Shiley K
中科院分区：
文献类型：
--
作者：
Alsolami A;Shiley K
1例流感相关的急性坏死性脑炎（ANE）是在一个健康的成年人。患者成功地治疗了高剂量甲基强的松龙和高剂量奥司他韦的组合。患者在停用150 mg每日两次奥司他韦后复发，但在重新开始高剂量奥司他韦治疗2周后迅速好转并最终痊愈。现就流感相关ANE的临床表现、发病机制和治疗进行综述。高剂量奥司他韦与甲基强的松龙联合使用可能会为这种罕见且知之甚少的流感感染并发症提供额外的治疗益处。
A case of influenza-associated acute necrotizing encephalitis (ANE) is described in an otherwise healthy adult. The patient was treated successfully with a combination of high-dose methylprednisolone and high-dose oseltamivir. The patient relapsed after discontinuing 150 mg twice daily oseltamivir but quickly improved and eventually recovered after reinitiation of high-dose oseltamivir for an additional 2 weeks. The clinical presentation, pathogenesis, and treatment of influenza-associated ANE is reviewed. The use of high-dose oseltamivir in combination with methylprednisolone may offer additional therapeutic benefit for this rare and poorly understood complication of influenza infection.