Mechanisms of small cell lung cancer metastasis.
Mechanisms of small cell lung cancer metastasis.
复制标题
小细胞肺癌转移的机制。
DOI：
10.15252/emmm.202013122
复制
发表时间：
2021-01-11
影响因子：
11.1
通讯作者：
Sage J
中科院分区：
文献类型：
--
作者：
Ko J;Winslow MM;Sage J
转移是癌症患者发病和死亡的主要原因。然而，癌细胞转移能力背后的分子和细胞机制仍然相对知之甚少。在所有实体瘤中，小细胞肺癌(SCLC)具有显著的转移倾向，大多数患者被诊断为转移性疾病。多年来，由于缺乏来自原发肿瘤和转移瘤的材料，以及缺乏可靠的临床前模型，我们对小细胞肺癌转移的理解一直受到阻碍。在这里，我们回顾了帮助绕过这些限制的最新进展。这些进展包括利用小细胞肺癌患者血液中的循环肿瘤细胞的方法，以及开发各种转移性小细胞肺癌的基因工程小鼠模型。对小细胞肺癌转移的细胞机制的新见解包括观察与转移能力增加相关的细胞命运变化。正在进行的关于细胞迁移和器官趋向性的研究有望扩大我们对小细胞肺癌转移的理解。最终，对转移表型的更好的分子理解可能转化为限制转移扩散和治疗转移的小细胞肺癌的新的治疗选择。小细胞肺癌(SCLC)是一种高度转移性的肿瘤，但罕见的SCLC肿瘤切除和转移阻碍了我们对SCLC进展的理解。本文就近年来有关小细胞肺癌转移模型和机制的研究进展作一综述。
Metastasis is a major cause of morbidity and mortality in cancer patients. However, the molecular and cellular mechanisms underlying the ability of cancer cells to metastasize remain relatively poorly understood. Among all solid tumors, small cell lung cancer (SCLC) has remarkable metastatic proclivity, with a majority of patients diagnosed with metastatic disease. Our understanding of SCLC metastasis has been hampered for many years by the paucity of material from primary tumors and metastases, as well as the lack of faithful pre‐clinical models. Here, we review recent advances that are helping circumvent these limitations. These advances include methods that employ circulating tumor cells from the blood of SCLC patients and the development of diverse genetically engineered mouse models of metastatic SCLC. New insights into the cellular mechanisms of SCLC metastasis include observations of cell fate changes associated with increased metastatic ability. Ongoing studies on cell migration and organ tropism promise to expand our understanding of SCLC metastasis. Ultimately, a better molecular understanding of metastatic phenotypes may be translated into new therapeutic options to limit metastatic spread and treat metastatic SCLC. Small cell lung cancer (SCLC) is highly metastatic, but rare resections of SCLC tumors and metastases have hampered our understanding of SCLC progression. This review offers a comprehensive overview of recent advances on models and mechanisms of SCLC metastasis.