Prevalence, Concomitance, and Distribution of Ossification of the Spinal Ligaments: Results of Whole Spine CT Scans in 1500 Japanese Patients
Prevalence, Concomitance, and Distribution of Ossification of the Spinal Ligaments: Results of Whole Spine CT Scans in 1500 Japanese Patients
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DOI：
10.1097/brs.0000000000001643
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发表时间：
2016-11-01
期刊：
影响因子：
3
通讯作者：
Oda, Takenori
中科院分区：
文献类型：
--
作者：
Fujimori, Takahito;Watabe, Tadashi;Oda, Takenori
研究设计。横断面研究目的：利用计算机断层扫描（CT）研究健康人不同类型脊柱韧带骨化的患病率、并发性和分布。背景资料摘要。与x线平片相比，CT对脊柱韧带骨化的诊断准确性更高。方法：纳入2006年至2013年间在一家私人健康检查中心接受正电子发射断层扫描和CT （PETCT）检查的1500名日本患者（男性888名，女性612名）。这项PETCT是对自费参与者进行的预防性癌症筛查。检查后纵韧带（OPLL）、黄韧带（OLF）、前纵韧带（OALL）、弥漫性特发性骨骼增生（DISH）和颈韧带（ONL）是否存在骨化。结果脊柱韧带骨化的发生率为：颈后纵韧带骨化6.3%（男性8.3%，女性3.4%），颈后纵韧带骨化23%（男性33%，女性8.8%），胸后纵韧带骨化1.6%（男性1.4%，女性2.0%）。12%为胸段黄韧带骨化（男性15%，女性7.7%），37%为胸腰段OALL（男性45%，女性26%），12%为DISH（男性16%，女性6.2%）。13%的颈椎OPLL患者患有胸椎OPLL， 34%的颈椎OPLL患者患有胸椎OLF， 45%的颈椎OPLL患者患有ONL， 36%的颈椎OPLL患者患有DISH。颈椎骨化最常见的水平为C5，胸椎骨化最常见的水平为T1/2，胸椎骨化最常见的水平为T11，胸椎骨化最常见的水平为T8/9。在脊髓韧带骨化的各个分类中观察到高度的共同性。证据等级：3
Study Design.Cross-sectional study.Objective.To investigate the prevalence, concomitance, and distribution of various types of ossification of the spinal ligaments in healthy subjects using computed tomography (CT).Summary of Background Data.CT has better diagnostic accuracy for ossification of the spinal ligaments compared to plain radiography. Currently there is no study that examines the prevalence of ossification of the spinal ligaments using whole spine CT scans.Methods.One thousand five hundred Japanese patients (888 men and 612 women) who underwent positron emission tomography and CT (PETCT) in a private health check center between 2006 and 2013 were included. This PETCT was performed on self-paying participants as a preventive cancer screen. Existence of ossification of the posterior longitudinal ligament (OPLL), ligamentum flavum (OLF), anterior longitudinal ligament (OALL), diffuse idiopathic skeletal hyperostosis (DISH), and nuchal ligament (ONL) was examined.Results.The prevalence of spinal ligament ossifications was found to be 6.3% in cervical OPLL (8.3% in men and 3.4% in women), 23% in ONL (33% in men and 8.8% in women), 1.6% in thoracic OPLL (1.4% in men and 2.0% in women), 12% in thoracic OLF (15% in men and 7.7% in women), 37% in thoracolumbar OALL (45% in men and 26% in women), and 12% in DISH (16% in men and 6.2% in women). Thirteen percent of patients with cervical OPLL had thoracic OPLL, 34% of cervical OPLL had thoracic OLF, 45% of cervical OPLL had ONL, and 36% of cervical OPLL had DISH. The most common level was C5 for cervical OPLL, T1/2 for thoracic OPLL, T11 for thoracic OLF, and T8/9 for OALL.Conclusion.Accurate prevalence of various types of ossification of the spinal ligaments evaluated by CT was revealed. High concomitance was observed in each classification of spinal ligament ossification.Level of Evidence: 3