Toxoplasma gondii microneme proteins: gene cloning and possible function.
Toxoplasma gondii microneme proteins: gene cloning and possible function.
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DOI：
10.1007/978-3-642-51014-4_5
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发表时间：
1996
影响因子：
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通讯作者：
M. Fourmaux;N. Garcia-Réguet;Odile Mercereau-Puijalon;J. Dubremetz
中科院分区：
文献类型：
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作者：
M. Fourmaux;N. Garcia-Réguet;Odile Mercereau-Puijalon;J. Dubremetz
在所有顶复门的侵入阶段，顶丝是以不同数量发现的小的顶端细胞器。据信，它们在入侵时通过胞吐其内容物而在识别宿主细胞中起作用，但很少获得这种胞吐作用的直接证据（ENTZEROTH等，1992）。相反，在几种模型中，已知储存在微线体中的分子已显示出具有粘附结构域甚至结合特性，这解释了生物体的宿主细胞特异性（亚当斯等，1990; TOMLEY等，1991; ESCHENBACHER等，1993）。在疟原虫属中尤其如此，其中红细胞和肝细胞结合分子近年来已被广泛表征（亚当斯等，1992; CERAMI等，1992; CHITNIS等，1994; SIM等，1994; ROBSON等，1995）。
Micronemes are small apical organelles found in variable amounts in the invasive stages of all Apicomplexa. They are believed to playa role in recognition of the host cell by exocytosing their contents at the time of invasion, but very little direct evidence of this exocytosis has been obtained (ENTZEROTH et al. 1992). Rather, in several models, molecules known to be stored in micronemes have been shown to possess adhesive domains or even binding properties, explaining the host cell specificity of the organism (ADAMS et al. 1990; TOMLEY et al. 1991; ESCHENBACHER et al. 1993). This is especially true in Plasmodium sp., in which erythrocyte and hepatocyte binding molecules have been extensively characterized in recent years (ADAMS et al. 1992; CERAMI et al. 1992; CHITNIS et al. 1994; SIM et al. 1994; ROBSON et al. 1995).