Investigations of Bis(alkylthiocarbamato)copper Linkage Isomers
Investigations of Bis(alkylthiocarbamato)copper Linkage Isomers
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双(烷硫基氨基甲酸酯)铜连接异构体的研究
DOI：
10.1021/acs.inorgchem.2c00371
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发表时间：
2022
影响因子：
4.6
通讯作者：
Grapperhaus, Craig A.
中科院分区：
文献类型：
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作者：
Bajaj, Kritika;Andres, Sarah A.;Hofsommer, Dillon T.;Galib, Mirza;Mashuta, Mark S.;Bennett, Brian;Narayanan, Badri;Buchanan, Robert M.;Bates, Paula J.;Grapperhaus, Craig A.
连接异构体是具有相同组成但给体原子不同的配位化合物，导致不同的物理和电子结构。合成、分离了一对源自苯基乙二醛双(乙基硫代氨基甲酸酯)的连接异构体CuL555和CuL465，并通过结构、电化学和光谱方法对其进行了表征。这些异构体在环境条件下在溶液中稳定，但 CuL465 在酸中会转化为 CuL555，这与量子化学计算一致。针对肺腺癌细胞系 (A549) 和非恶性肺成纤维细胞系 (IMR-90) 筛选复合物以评估抗增殖活性。CuL555 和 CuL465 的 EC50 值分别为 0.113 ± 0.030 和 0.115 ± 0.038 μM（对于 A549 和 1.87 ± 0.29） IMR-90 分别为 0.77 ± 0.22 μM。
Linkage isomers are coordination compounds with the same composition but different donor atoms, resulting in distinct physical and electronic structures. A pair of linkage isomers,CuL555andCuL465, derived from phenylglyoxal bis(ethylthiocarbamate) were synthesized, isolated, and characterized by structural, electrochemical, and spectroscopic methods. The isomers are stable in solution under ambient conditions, butCuL465converts toCuL555in acid, consistent with quantum-chemical calculations. The complexes were screened against a lung adenocarcinoma cell line (A549) and a nonmalignant lung fibroblast cell line (IMR-90) to evaluate the antiproliferation activity.CuL555andCuL465possessed EC50values of 0.113 ± 0.030 and 0.115 ± 0.038 μM for A549 and 1.87 ± 0.29 and 0.77 ± 0.22 μM for IMR-90, respectively.