PHASIC SYNAPTIC INCORPORATION OF GLUR2-LACKING AMPA RECEPTORS AT GONADOTROPIN-RELEASING HORMONE NEURONS IS INVOLVED IN THE GENERATION OF THE LUTEINIZING HORMONE SURGE IN FEMALE RATS
PHASIC SYNAPTIC INCORPORATION OF GLUR2-LACKING AMPA RECEPTORS AT GONADOTROPIN-RELEASING HORMONE NEURONS IS INVOLVED IN THE GENERATION OF THE LUTEINIZING HORMONE SURGE IN FEMALE RATS
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DOI：
10.1016/j.neuroscience.2013.06.040
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发表时间：
2013-09-17
期刊：
影响因子：
3.3
通讯作者：
Takahashi, T.
中科院分区：
文献类型：
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作者：
Tada, H.;Kuroki, Y.;Takahashi, T.
生殖成功取决于排卵前黄体生成素（LH）激增的稳定和适当时间，这是由促性腺激素释放激素（GnRH）神经元激活引起的，以响应雌激素水平增加的正反馈。在这里，我们的文件增加突触后GluR 2缺乏Ca 2+渗透AMPA型谷氨酸受体（CP-AMPAR）在大鼠动情前期的一天，在GnRH神经元的突触，与雌激素水平的增加。功能性阻断CP-AMPARs只在动情前期抑制突触反应，同时减弱LH峰。因此，GnRH神经元上突触后CP-AMPAR的阶段性突触掺入参与LH峰的产生。(C)2013年IBRO。由爱思唯尔有限公司出版。保留所有权利。
Reproductive success depends on a robust and appropriately timed preovulatory luteinizing hormone (LH) surge, which is induced by the activation of gonadotropin-releasing hormone (GnRH) neurons in response to positive feedback from increasing estrogen levels. Here we document an increase in postsynaptic GluR2-lacking Ca2+-permeable AMPA-type glutamate receptors (CP-AMPARs) at synapses on GnRH neurons on the day of proestrus in rats, coincident with the increase in estrogen levels. Functional blockade of CP-AMPARs depressed the synaptic responses only on the day of proestrus and concomitantly attenuated the LH surge. Thus, the phasic synaptic incorporation of postsynaptic CP-AMPARs on GnRH neurons is involved in the generation of the LH surge. (C) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.