Expression of p38 MAPK in mouse testis during postnatal development
Expression of p38 MAPK in mouse testis during postnatal development
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发表时间：
2003
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通讯作者：
Jiang Er
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作者：
Jiang Er
目的：研究p38丝裂原活化蛋白激酶（p38 MAPK）在小鼠生后睾丸发育过程中的表达。方法：采用免疫组织化学SABC法检测1 ~ 7周龄小鼠睾丸组织中p38 MAPK的表达。结果：2周龄小鼠睾丸精原细胞中可见p38 MAPK免疫染色。在3 ~ 5周龄小鼠睾丸中，仅有少数曲细精管表达p38 MAPK，而在6、7周龄小鼠睾丸中，p38 MAPK表达丰富。p38 MAPK免疫定位于精原细胞和初级精母细胞，阳性物质位于细胞核内。另外，7周龄小鼠睾丸间质细胞部分p38 MAPK阳性，胞浆内有阳性物质。结论：p38 MAPK可能参与了生精细胞增殖和雄激素分泌的调节。
AIM: To study the expression of p38 MAPK in mouse testis during postnatal development. METHODS: Immunohistochemical SABC method was used to detect the expression of p38 MAPK in 1 to 7 week old mice testes. RESULTS: The immunostaining of p38 MAPK was seen in spermatogonium of 2 week old mice testes. Only a few seminiferous tubules were p38 MAPK positive in 3 to 5 week old mice, whereas the expression of p38 MAPK was abundant in the testes of 6 and 7 week old mice. The immunolocalization of p38 MAPK was in spermatogonium and primary spermatocyte with positive substance in nucleus. In addition, some Leydig cells were p38 MAPK positive in the testes of 7 week old mice with positive substance in cytoplasm. CONCLUSION: p38 MAPK may play a role in the regulation of spermatogenic cell proliferation and androgen secretion.