microRNAs and angiogenesis in endometriosis
microRNAs and angiogenesis in endometriosis
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DOI：
10.1016/s0049-3848(15)50439-8
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发表时间：
2015-02-01
影响因子：
7.5
通讯作者：
Gilabert-Estelles, Juan
中科院分区：
文献类型：
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作者：
Mari-Alexandre, Josep;Garcia-Oms, Javier;Gilabert-Estelles, Juan
MiRNAs通过转录后基因表达调控，对血管生成和纤溶等广泛的细胞过程发挥重要的调节作用。我们就miRNAs和血管生成在子宫内膜异位症中的作用作一综述。子宫内膜异位症是指子宫内膜组织植入子宫腔外，是最常见的良性妇科疾病之一，它对患者的生活质量和生育能力有重要影响。与肿瘤转移相似，异位内膜具有黏附、增殖和渗入细胞外基质的能力。子宫内膜异位症是一种多因素、多基因的疾病，可能涉及血管生成和蛋白分解，越来越多的证据表明miRNA表达的失调可能参与了这些过程。血浆和其他体液中循环miRNAs的检测及其相对稳定性增加了它们可能作为非侵入性生物标志物用于疾病诊断的可能性。另一方面，可能阻断miRNAs表达或模拟miRNAs功能的治疗方法的发展可能代表着治疗子宫内膜异位症的新的治疗策略。(C)2015爱思唯尔有限公司。保留所有权利。
miRNAs function as important regulators of a wide range of cellular processes, such as angiogenesis and fibrinolysis, by postranscriptional modulation of gene expression. We present a review on the role of miRNAs and angiogenesis in endometriosis.Endometriosis, defined as the implantation of endometrial tissue outside the uterine cavity, is one of the most frequent benign gynecological diseases and it has important consequences on the quality of life and fertility of patients. Similarly to tumor metastasis, the ectopic endometrium acquires the capability to adhere, proliferate and infiltrate the extracellular matrix. Endometriosis is a multifactorial and polygenic disease in which angiogenesis and proteolysis may be involved, and emerging data provide evidence that a dysregulation of miRNA expression may be implicated in these processes. The detection of circulating miRNAs in plasma and other body fluids and their relative stability has raised the possibility that they might serve as non-invasive biomarkers for the diagnosis of the disease. On the other hand, the development of therapies that might block the expression or mimic the functions of miRNAs could represent new therapeutic strategies for the treatment of endometriosis. (C) 2015 Elsevier Ltd. All rights reserved.