Number of boys born to men exposed to polychlorinated byphenyls
Number of boys born to men exposed to polychlorinated byphenyls
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DOI：
10.1016/s0140-6736(02)09386-8
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发表时间：
2002-07-13
期刊：
影响因子：
168.9
通讯作者：
Guo, YLL
中科院分区：
文献类型：
--
作者：
Gomez, LD;Marshall, T;Guo, YLL
我们研究了在1979年台湾禹城漏油事故中暴露于多氯联苯（PCBs）的个体所生子女的性别。20岁之前暴露于PCB的男性生男孩的机会低于年龄匹配和邻居匹配的对照组（比值比0.65，95%CI 0.45-0.93）。然而，接触多氯联苯的男性在20岁以后所生子女的男女性别比接近对照组（0.90，0.59-1.35）。我们注意到，暴露和未暴露母亲所生婴儿的出生率没有显著差异（0.93，0.77-1.12）。我们的研究结果表明，父亲在20岁之前接触多氯联苯会影响随后出生的孩子的性别。
We studied the sex of children born to individuals involved in the Yucheng oil disaster, Taiwan, who were exposed to polychlorinated byphenyls (PCBs) after an oil contamination accident in 1979. Men exposed to PCBs before age 20 years had a lower chance of having a baby boy than did age-matched and neighbourhood-matched controls (odds ratio 0.65, 95% CI 0.45-0.93). The male-to-female sex ratio of children born to men exposed to PCBs after age 20 years, however, approached that seen in controls (0.90, 0.59-1.35). We noted no significant difference in the birth ratio of infants born to exposed and unexposed mothers (0.93, 0.77-1.12). Our findings suggest that paternal exposure to PCBs before age 20 years affects the sex of a subsequently born child.