Effect of Korean Red Ginseng on Noise-Induced Hearing Loss.
Effect of Korean Red Ginseng on Noise-Induced Hearing Loss.
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红参对噪声性听力损失的影响。
DOI：
10.4274/tao.2021.2021-1-5
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发表时间：
2021-06
影响因子：
0.6
通讯作者：
Kırkım G
中科院分区：
文献类型：
--
作者：
Mungan Durankaya S;Olgun Y;Aktaş S;Eskicioğlu HE;Gürkan S;Altun Z;Mutlu B;Kolatan E;Doğan E;Yılmaz O;Kırkım G
噪声性听力损失（NIHL）是影响患者社会和职业生活的最重要问题之一。没有一种治疗方法被认为是成功的听力损失，已成为一个永久性的性质。本研究的目的是评估韩国红参（KRG）对NIHL动物模型的保护作用。将28只大鼠分为4组[对照盐水组（I组）、对照KRG组（II组）、盐水+噪声组（III组）、KRG+噪声组（IV组）]。生理盐水组和KRG组大鼠经口灌胃给予200 mg/kg/天剂量，持续10天。14只大鼠（组III和组IV）暴露于120 dB SPL的4 kHz倍频程噪声5小时。在噪声暴露前和暴露后第1、7、10天，用畸变产物耳声发射（DPOAE）和听性脑干反应（ABR）检测大鼠4、8、12、16、32kHz的听力水平。第10天末次听力学检查后处死大鼠。光镜下观察耳蜗和螺旋神经节组织。听力学和组织学结果表明，噪声后，第IV组表现出比第III组更好的结果。在噪声暴露组中，在8kHz频率区域观察到最显著的损伤。噪声暴露后，第1、7、10次DPOAE反应均消失。因此，我们无法对DPOAE结果进行任何统计分析。我们的研究结果表明，KRG似乎是一个有效的代理对NIHL。有必要进行更多的研究，以了解KRG的保护作用的机制。
Noise-induced hearing loss (NIHL) is one of the most important problems affecting both social and professional life of patients. There is no treatment method considered to be successful on the hearing loss that has become a permanent nature. Aim of this study is to evaluate protective effect of Korean Red Ginseng (KRG) against NIHL in an animal model. Twenty-eight rats were separated into four groups [control saline (group I), control KRG (group II), saline + noise (group III), KRG + noise (group IV)]. Rats in the saline and KRG groups were fed via oral gavage with a dose of 200 mg/kg/day throughout for 10 days. Fourteen rats (group III and IV) were exposed to 4 kHz octave band noise at 120 dB SPL for 5 hours. Hearing levels of rats were evaluated by distortion product otoacoustic emissions (DPOAE) and auditory brainstem responses (ABR) at 4, 8, 12, 16 and 32 kHz frequencies prior to and on days 1, 7 and 10 after the noise exposure. Rats were sacrificed on 10th day, after the last audiological test. Cochlea and spiral ganglion tissues were evaluated by light microscopy. Audiological and histological results demonstrated that after noise the group IV showed better results than group III. In the noise exposed groups, the most prominent damage was seen at the 8 kHz frequency region than other regions. After the noise exposure, DPOAE responses were lost in 1st, 7th and 10th measurements in both group III and IV. Thus, we were not able to perform any statistical analyses for DPOAE results. Our findings suggest that KRG seems to be an efficient agent against NIHL. There is need for additional research to find out about the mechanisms of KRG’s protective effect.