Design and Characterization of a Volume-Cycled Small Animal Mechanical Ventilator Coupled with a Respiratory System Model
Design and Characterization of a Volume-Cycled Small Animal Mechanical Ventilator Coupled with a Respiratory System Model
复制标题
与呼吸系统模型相结合的容量循环小动物机械呼吸机的设计和表征
DOI：
10.1007/978-3-319-13117-7_9
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发表时间：
2015
影响因子：
3.2
通讯作者：
H. T. Moriya
中科院分区：
文献类型：
--
作者：
R. Bonatti;A. F. Cruz;H. T. Moriya
小鼠等小动物通常用于研究药物影响下呼吸系统行为的实验中，由于所涉及的体积小，因此需要精确的气体流量测量。基于这一需求，开发了一种用于小动物的机械呼吸机，其使用线性致动器与由驱动器控制的3ml精密玻璃注射器耦合。用该机器对由内容积为78ml的刚性塑料圆筒组成的代表小鼠呼吸系统的机械负荷进行通气，并将其测量的阻力和弹性参数与理论数学模型获得的值进行比较。与预测值相比，模型的弹性最大偏差为12.7%，测量的电阻并没有假设线性系统的预期行为，随着频率的增加急剧下降。
Small animals such as mice are generally used in experiments that study the behavior of the respiratory system under the influence of drugs, and accurate gas flow measurements are necessary due to the small volumes involved. Based on this need, a mechanical ventilator for small animals was developed using a linear actuator coupled with a 3ml precision glass syringe controlled by a driver. A mechanical load representing a mouse’s respiratory system consisting of a rigid plastic cylinder with internal volume of 78ml was ventilated by the machine, and its measured resistance and elastance parameters were compared to values obtained with theoretical mathematical models. A 12.7% maximum deviation was found in the model’s elastance in comparison with the predicted value, and the measured resistance did not assume the expected behavior of a linear system, decreasing sharply with the increase of frequency.