Tumor Cellular and Microenvironmental Cues Controlling Invadopodia Formation.
Tumor Cellular and Microenvironmental Cues Controlling Invadopodia Formation.
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肿瘤细胞和微环境线索控制Invadopodia形成。
DOI：
10.3389/fcell.2020.584181
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发表时间：
2020
影响因子：
5.5
通讯作者：
Rosanò L
中科院分区：
文献类型：
--
作者：
Masi I;Caprara V;Bagnato A;Rosanò L
在转移进展过程中，入侵细胞可能实现降解，并随后侵入细胞外基质（ECM）和底层血管系统使用侵袭伪足，F-肌动蛋白为基础的和力支持的膨胀膜结构，操作集中的蛋白水解。它们的形成是一个动态过程，需要ECM修饰蛋白与细胞受体的组合和协同活性，以及与肿瘤微环境（TME）因子的相互作用。在理解侵袭性伪足如何组装以及它们如何在降解性突起中进展以及它们的分解以及细胞信号与控制侵袭性伪足形成和活性的ECM条件之间的合作方面已经取得了重大进展，有望转化为用于治疗干预的分子靶点的鉴定。这些发现揭示了不仅在侵袭伪足的肌动蛋白核心和特定的细胞内结构（包括细胞核、微管网络和囊泡运输参与者）之间存在生物化学和机械相互作用，而且还与TME的元素（如基质细胞、ECM组分、机械力和代谢条件）存在生物化学和机械相互作用。这些相互作用反映了入侵伪足的复杂性和复杂的调节，并表明它们的形成和功能的许多方面仍有待确定。在这篇综述中，我们将提供一个简单的描述invadopodia和解决他们的调节细胞信号以及从TME输入的最新研究结果。这些输入之间的识别和相互作用将提供对转移过程中细胞侵袭的更深入的机制理解，并将有助于开发更有效的治疗策略。
During the metastatic progression, invading cells might achieve degradation and subsequent invasion into the extracellular matrix (ECM) and the underlying vasculature using invadopodia, F-actin-based and force-supporting protrusive membrane structures, operating focalized proteolysis. Their formation is a dynamic process requiring the combined and synergistic activity of ECM-modifying proteins with cellular receptors, and the interplay with factors from the tumor microenvironment (TME). Significant advances have been made in understanding how invadopodia are assembled and how they progress in degradative protrusions, as well as their disassembly, and the cooperation between cellular signals and ECM conditions governing invadopodia formation and activity, holding promise to translation into the identification of molecular targets for therapeutic interventions. These findings have revealed the existence of biochemical and mechanical interactions not only between the actin cores of invadopodia and specific intracellular structures, including the cell nucleus, the microtubular network, and vesicular trafficking players, but also with elements of the TME, such as stromal cells, ECM components, mechanical forces, and metabolic conditions. These interactions reflect the complexity and intricate regulation of invadopodia and suggest that many aspects of their formation and function remain to be determined. In this review, we will provide a brief description of invadopodia and tackle the most recent findings on their regulation by cellular signaling as well as by inputs from the TME. The identification and interplay between these inputs will offer a deeper mechanistic understanding of cell invasion during the metastatic process and will help the development of more effective therapeutic strategies.
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影响因子：
6.6
作者：
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通讯作者：
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影响因子：
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Condeelis, John
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3.3
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通讯作者：
Condeelis J