Detection of ototoxicity from drugs applied topically to the middle ear space
Detection of ototoxicity from drugs applied topically to the middle ear space
复制标题
检测局部应用于中耳间隙的药物的耳毒性
DOI：
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发表时间：
1976
期刊：
影响因子：
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通讯作者：
John A Lindgren
中科院分区：
文献类型：
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作者：
R. Brummett;R. F. Harris;John A Lindgren
本文总结了我们实验室进行的两项独立研究的数据。这两项研究都是为了调查通常应用于中耳间隙的药物可能导致感觉神经性听力损失的可能性。被认为最有可能用于研究的两种药物是新霉素和多粘菌素b。在新霉素研究中，不同浓度的药物每天服用三次，持续四周。在多粘菌素B研究中，每天给药三次，持续两周。通过电生理和耳蜗表面的检查来评价耳蜗的功能。
This paper summarizes data obtained from two separate studies done in our laboratory. Both studies were done to investigate the possibility that drugs commonly applied to the middle ear space could be the cause of sensori‐neural hearing loss. The two drugs that were felt to be the most likely candidates for the studies were neomycin and polymyxin B. In the neomycin study, the various drug concentrations were administered three times a day for four weeks. In the polymyxin B study, the administration was three times a day for two weeks. Cochlear function was evaluated electrophysiologically and by examination of surface preparations of the organ of Corti.