BONE MASS, BONE-STRUCTURE AND VERTEBRAL FRACTURES IN OSTEOPOROTIC PATIENTS
BONE MASS, BONE-STRUCTURE AND VERTEBRAL FRACTURES IN OSTEOPOROTIC PATIENTS
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DOI：
10.1016/8756-3282(87)90010-x
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发表时间：
1987-01-01
期刊：
影响因子：
4.1
通讯作者：
CHRISTIANSEN, C
中科院分区：
文献类型：
--
作者：
PODENPHANT, J;NIELSEN, VAH;CHRISTIANSEN, C
对44例绝经后骨质疏松症妇女的临床骨疾病严重程度进行了研究。评估脊柱X线片，并与骨量和骨结构的客观测量值进行比较;通过单光子吸收测定法测量前臂骨矿物质含量（BMCarm），通过双光子吸收测定法测量全身骨矿物质含量（TBBM）和脊柱骨矿物质含量（BMCspine），通过髂嵴活检测量校正皮质宽度（C Cor W）、骨小梁体积（TBV）和骨小梁微结构指数。为了比较25名绝经后正常人的BMC臂、TBBM和BMC脊柱的数据。结果显示，与正常人相比，骨折患者的皮质骨和松质骨的数量减少。将骨折患者分为两组，即26例单纯楔形骨折患者和18例压缩性（+楔形）骨折患者，结果显示后一组患者的骨小梁丢失更严重，骨小梁显微结构进一步恶化。在个体基础上，无法证明骨病的临床严重程度与骨量和骨结构之间存在一致性。
The clinical severity of bone disease was studied in 44 post-menopausal osteoporotic women. Spinal x-rays were assessed and compared to objective measurements of bone mass and bone structure; forearm bone mineral content (BMCarm) by single photon absorptiometry, total body bone mineral content (TBBM), and spinal bone mineral content (BMCspine) by dual photon absorptiometry, and corrected cortical width (C Cor W), trabecular bone volume (TBV), and indices of trabecular microstructure by iliac crest biopsy. For comparison data of BMCarm, TBBM and BMCspine in 25 postmenopausal normals are shown. The results showed a reduction in amount of both cortical and trabecular bone in the fracture patients compared to normals. A subdivision of the fracture patients into two groups constituting 26 patients with wedge fractures alone and 18 patients wtih compression (+wedge) fractures showed that the latter group had a further predominantly trabecular bone loss and a further deteriorated trabecular microstructure. On an individual basis no agreement between clinical severity of bone disease and amount and structure of bone could be demonstrated.